Evidence map›Paper›PMID 33916612›Full record

ReviewFoods (Basel, Switzerland)2021

Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds.

Abigail Raffner Basson, Saleh Ahmed, Rawan Almutairi, Brian Seo, Fabio Cominelli

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Gut microbiota metabolic axis dysfunction in estrogen deficient stressed rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  6. Article
  7. Heat-TreatedJournal of microbiology and biotechnology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Soybean (International journal of molecular sciences · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Abigail Raffner BassonDivision of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-8369-919X
Saleh AhmedDigestive Health Research Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Rawan AlmutairiDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Brian SeoDigestive Health Research Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Fabio CominelliDivision of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
University Hospitals of Cleveland · USCase Western Reserve University · US

Funding

Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
Effect of an Anti-Inflammatory Diet on Gut Homeostasis in Active and Experimental Crohn's DiseaseK01DK127008 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAFFNER, ABIGAIL · 2021 to 2025
$610k
Functional characterization of human gut microbiota's response to diet in two gnotobiotic SAMP1/YitFc mouse models of Crohn's disease ileitisF32DK117585 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAFFNER, ABIGAIL · 2018 to 2018
$64k
NIDDK NIH HHS K01 DK127008NIH HHS 1P30DK097948NIH HHS DK055812NIH HHS DK091222NIH HHS DK097948NIH HHS F32DK117585NIH HHS T32DK083251
6 · The paper itself

Abstract

Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean.

Indexed as

bioactive compoundCrohn’s diseaseinflammationinflammatory bowel diseaseisoflavoneisoflavonesplant-basedwestern diet

Identifiers

PMID33916612
PMCPMC8066255
OpenAlexW3141905459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.