Evidence map›Paper›PMID 33916601›Full record

ArticleViruses2021

Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness.

Lirong Cao, Shi Zhao, Jingzhi Lou, Hong Zheng, Renee W Y Chan, Marc K C Chong, Zigui Chen, Paul K S Chan, Benny C Y Zee, Maggie H Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Lirong CaoJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0002-5793-3878
Shi ZhaoJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0001-8722-6149
Jingzhi LouJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Hong ZhengJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Renee W Y ChanHong Kong Hub of Paediatric Excellence, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0001-6485-0926
Marc K C ChongJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0001-5610-1298
Zigui ChenDepartment of Microbiology, Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0002-8577-1298
Paul K S ChanDepartment of Microbiology, Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Benny C Y ZeeJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.ORCID 0000-0002-7238-845X
Maggie H WangJC School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Chinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children's group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens.

Indexed as

Vaccine PotencyAdolescentAdultAgedAge FactorsCase-Control StudiesChildChild, PreschoolHemagglutinins, ViralHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesMiddle AgedHemagglutinins, ViralInfluenza VaccinesNeuraminidaseage-related effectsA(H1N1)pdm09genetic mismatchinfluenza vaccine effectiveness

Identifiers

PMID33916601
PMCPMC8065480
OpenAlexW3151913992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.