Evidence map›Paper›PMID 33916572›Full record

ArticleInternational journal of molecular sciences2021

Acidified Nitrite Contributes to the Antitumor Effect of Cold Atmospheric Plasma on Melanoma Cells.

Tom Zimmermann, Lisa A Gebhardt, Lucas Kreiss, Christin Schneider, Stephanie Arndt, Sigrid Karrer, Oliver Friedrich, Michael J M Fischer, Anja-Katrin Bosserhoff

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. A metabolic perspective on nitric oxide function in melanoma.Biochimica et biophysica acta. Reviews on cancer · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Plasma Biology.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tom ZimmermannEmil-Fischer-Center, Institute of Biochemistry, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Lisa A GebhardtInstitute of Physiology and Pathophysiology, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Lucas KreissDepartment of Medicine I, University Clinics Erlangen, 91054 Erlangen, Germany.
Christin SchneiderEmil-Fischer-Center, Institute of Biochemistry, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.
Stephanie ArndtDepartment of Dermatology, University Hospital of Regensburg, 93053 Regensburg, Germany.
Sigrid KarrerDepartment of Dermatology, University Hospital of Regensburg, 93053 Regensburg, Germany.
Oliver FriedrichInstitute of Medical Biotechnology, University of Erlangen-Nuernberg, 91052 Erlangen, Germany.ORCID 0000-0003-2238-2049
Michael J M FischerInstitute of Physiology and Pathophysiology, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.ORCID 0000-0002-3811-7066
Anja-Katrin BosserhoffEmil-Fischer-Center, Institute of Biochemistry, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.ORCID 0000-0001-8147-394X
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity Hospital Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft BO1573/23
6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) is partially ionized gas near room temperature with previously reported antitumor effects. Despite extensive research and growing interest in this technology, active components and molecular mechanisms of CAP are not fully understood to date. We used Raman spectroscopy and colorimetric assays to determine elevated nitrite and nitrate levels after treatment with a MiniFlatPlaster CAP device. Previously, we demonstrated CAP-induced acidification. Cellular effects of nitrite and strong extracellular acidification were assessed using live-cell imaging of intracellular Ca

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell SurvivalDNA DamageHumansMAP Kinase Signaling SystemMelanomaNitritesPlasma GasesAntineoplastic AgentsNitritesPlasma Gasesacidificationacidified nitritecold atmospheric plasmamalignant melanomamembrane damagenitrationnitrite

Identifiers

PMID33916572
PMCPMC8038463
OpenAlexW3144768746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.