Evidence map›Paper›PMID 33916486›Full record

ArticleInternational journal of molecular sciences2021

Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice.

Merri-Grace Allred, Michael S Chimenti, Ashley E Ciecko, Yi-Guang Chen, Scott M Lieberman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Merri-Grace AllredStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Michael S ChimentiIowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Ashley E CieckoDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Yi-Guang ChenDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Scott M LiebermanStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-4082-7582
University of Iowa · USMedical College of Wisconsin · US

Funding

Mechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 DiabetesR01DK107541 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, RIDGWAY, WILLIAM M · 2016 to 2025
$5.6M
Cytokines driving T cell dysregulation in lacrimal gland autoimmunityR01EY027731 · NEI · UNIVERSITY OF IOWA · PI LIEBERMAN, SCOTT MATTHEW · 2018 to 2022
$2.4M
Shaping diabetogenic T cells by IL-27 in type 1 diabetesR01DK121747 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG · 2019 to 2022
$1.5M
Genetic analysis of islet-infiltrating IL-21-expressing CD4 T cells in type 1 diabetesR21AI144360 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG · 2020 to 2021
$418k
NEI NIH HHS R01 EY027731NIAID NIH HHS R21 AI144360NIDDK NIH HHS R01 DK107541NIDDK NIH HHS R01 DK121747NIH HHS AI110963NIH HHS EY027731
6 · The paper itself

Abstract

Type I interferons (IFNs) are required for spontaneous lacrimal gland inflammation in the nonobese diabetic (NOD) mouse model of Sjögren's disease, but the consequences of type I IFN signaling are not well-defined. Here, we use RNA sequencing to define cytokine and chemokine genes upregulated in lacrimal glands of NOD mice in a type I IFN-dependent manner. Interleukin (IL)-21 was the highest differentially expressed cytokine gene, and

Indexed as

AnimalsChemokine CXCL10Chemokine CXCL9InflammationInterleukin-21InterleukinsLacrimal ApparatusMiceMice, Inbred NODMice, KnockoutReceptors, CXCR3Signal TransductionT-Lymphocytes, RegulatoryChemokine CXCL10Chemokine CXCL9Cxcl10 protein, mouseCxcl9 protein, mouseCxcr3 protein, mouseInterleukin-21InterleukinsReceptors, CXCR3chemokinesinterleukin-21lacrimal glandnonobese diabetic miceSjögren’s diseasetype I interferon

Identifiers

PMID33916486
PMCPMC8038628
OpenAlexW3150114720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.