ArticleMolecules (Basel, Switzerland)2021
Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 69 citations in OpenAlex.
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- Optimization of Deep Eutectic Solvent-Based Ultrasound-Assisted Extraction of Bioactive Compounds from Maca Leaves Using the Taguchi Method.Molecules (Basel, Switzerland) · 2025Article
- Green Extraction of Antioxidant-Rich Flavonoids fromMolecules (Basel, Switzerland) · 2025Article
- Towards green extraction of bioactive natural compounds.Analytical and bioanalytical chemistry · 2024Article
- Natural Deep Eutectic Solvents for the Extraction of Spilanthol fromMolecules (Basel, Switzerland) · 2024Article
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- Dietary Fiber from Navel Orange Peel Prepared by Enzymatic and Ultrasound-Assisted Deep Eutectic Solvents: Physicochemical and Prebiotic Properties.Foods (Basel, Switzerland) · 2023Article
- Natural Deep Eutectic Solvents for the Extraction of Triterpene Saponins fromMolecules (Basel, Switzerland) · 2023Article
- Major Phytochemicals: Recent Advances in Health Benefits and Extraction Method.Molecules (Basel, Switzerland) · 2023Review
- Deep Eutectic Solvents as a Green Tool for the Extraction of Bioactive Phenolic Compounds from Avocado Peels.Molecules (Basel, Switzerland) · 2022Article
- The Impact of Natural Deep Eutectic Solvents and Extraction Method on the Co-Extraction of Trace Metals fromMarine drugs · 2022Article
- Review
- Oriented Deep Eutectic Solvents as Efficient Approach for Selective Extraction of Bioactive Saponins from Husks ofAntioxidants (Basel, Switzerland) · 2022Article
- Extraction of Bioactive Compounds FromFrontiers in nutrition · 2022Article
- Applications for natural deep eutectic solvents in Chinese herbal medicines.Frontiers in pharmacology · 2022Review
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- Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal HalophyteMolecules (Basel, Switzerland) · 2021Article
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7 authors at 2 institutions in 1 country.
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Abstract
In the present study, a simple and environmentally friendly extraction method based on natural deep eutectic solvents (NADESs) was established to extract four bioactive steroidal saponins from Dioscoreae Nipponicae Rhizoma (DNR). A total of twenty-one types of choline chloride, betaine, and L-proline based NADESs were tailored, and the NADES composed of 1:1 molar ratio of choline chloride and malonic acid showed the best extraction efficiency for the four steroidal saponins compared with other NADESs. Then, the extraction parameters for extraction of steroidal saponins by selected tailor-made NADES were optimized using response surface methodology and the optimal extraction conditions are extraction time, 23.5 min; liquid-solid ratio, 57.5 mL/g; and water content, 54%. The microstructure of the DNR powder before and after ultrasonic extraction by conventional solvents (water and methanol) and the selected NADES were observed using field emission scanning electron microscope. In addition, the four steroidal saponins were recovered from NADESs by D101 macroporous resin with a satisfactory recovery yield between 67.27% and 79.90%. The present research demonstrates that NADESs are a suitable green media for the extraction of the bioactive steroidal saponins from DNR, and have a great potential as possible alternatives to organic solvents for efficiently extracting bioactive compounds from natural products.
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