Evidence map›Paper›PMID 33916385›Full record

ReviewNutrients2021

The Clinical Value of Nutritional Care before and during Active Cancer Treatment.

Giuseppe Aprile, Debora Basile, Renato Giaretta, Gessica Schiavo, Nicla La Verde, Ettore Corradi, Taira Monge, Francesco Agustoni, Silvia Stragliotto

Abstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Integrating psychological and dietary care for patients with advanced gastric cancer undergoing chemotherapy: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  5. Trial
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Optimizing Clinical Nutrition Management for Elderly Hospitalized Patients: Current Practices and Insights.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppe AprileDepartment of Oncology, AULSS8 Berica, 36100 Vicenza, Italy.
Debora BasileDepartment of Oncology, AULSS8 Berica, 36100 Vicenza, Italy.
Renato GiarettaDepartment of Oncology, AULSS8 Berica, 36100 Vicenza, Italy.
Gessica SchiavoClinical Nutritional Unit, AULSS8 Berica, 36100 Vicenza, Italy.
Nicla La VerdeDepartment of Oncology, PO Sacco, ASST Fatebenefratelli Sacco, 20131 Milano, Italy.
Ettore CorradiClinical Nutritional Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy.
Taira MongeClinical Nutrition, S. Giovanni Battista Hospital, 10126 Torino, Italy.
Francesco AgustoniMedical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Silvia StragliottoDepartment of Oncology, Istituto Oncologico Veneto-IRCCS, 31033 Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malnutrition and muscle wasting are frequently reported in cancer patients, either linked to the tumor itself or caused by oncologic therapies. Understanding the value of nutritional care during cancer treatment remains crucial. In fact, cancer-associated sarcopenia plays a key role in determining higher rates of morbidity, mortality, treatment-induced toxicities, prolonged hospitalizations and reduced adherence to anticancer treatment, worsening quality of life and survival. Planning baseline screening to intercept nutritional troubles earlier, organizing timely reassessments, and providing adequate counselling and dietary support, healthcare professional may positively interfere with this process and improve patients' overall outcomes during the whole disease course. Several screening tools have been proposed for this purpose. Nutritional Risk Screening (NRS), Mini Nutritional Assessment (MNA), Patient Generated Subjective Global Assessment (PG-SGA) are the most common studied. Interestingly, second-level tools including skeletal muscle index (SMI) and bioelectric impedance analysis (BIA) provide a more precise assessment of body composition, even if they are more complex. However, nutritional assessment is not currently used in clinical practice and procedures must be standardized in order to improve the efficacy of standard chemotherapy, targeted agents or even checkpoint inhibitors that is potentially linked with the patients' nutritional status. In the present review, we will discuss about malnutrition and the importance of an early nutritional assessment during chemotherapy and treatment with novel checkpoint inhibitors, in order to prevent treatment-induced toxicities and to improve survival outcomes.

Indexed as

Antineoplastic AgentsBody CompositionChemotherapy, AdjuvantElectric ImpedanceHumansMalnutritionNeoplasmsNutritional StatusNutritional SupportNutrition AssessmentProgression-Free SurvivalQuality of LifeSarcopeniaWasting SyndromeAntineoplastic Agentsmuscle wasting, malnutrition, nutritional intervention, nutritional care, sarcopenia

Identifiers

PMID33916385
PMCPMC8065908

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.