Evidence map›Paper›PMID 33916254›Full record

ReviewMicromachines2021

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering.

Ana Rita M P Santos, Yongjun Jang, Inwoo Son, Jongseong Kim, Yongdoo Park

Abstract readReview
In one paragraph

Review in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana Rita M P SantosBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.
Yongjun JangBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.ORCID 0000-0002-0508-4341
Inwoo SonBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.
Jongseong KimBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.ORCID 0000-0001-9595-2765
Yongdoo ParkBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Korea.ORCID 0000-0003-3822-4651

Funding

Korea University a Korea University GrantNational Research Foundation of Korea 2016-M3A9B6947892
6 · The paper itself

Abstract

Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering.

Indexed as

cardiac tissue engineeringcardiomyocytecomputational modelingextracellular matrixgeometryhuman pluripotent stem cellmaturation

Identifiers

PMID33916254
PMCPMC8067203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.