Evidence map›Paper›PMID 33916202›Full record

ArticleInternational journal of molecular sciences2021

Synthesis, Biological Activity, and Molecular Dynamics Study of Novel Series of a Trimethoprim Analogs as Multi-Targeted Compounds: Dihydrofolate Reductase (DHFR) Inhibitors and DNA-Binding Agents.

Agnieszka Wróbel, Maciej Baradyn, Artur Ratkiewicz, Danuta Drozdowska

Open access · goldAbstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

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  11. New Steroidal Selenides as Proapoptotic Factors.Molecules (Basel, Switzerland) · 2023
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  12. Antibiotics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Agnieszka WróbelDepartment of Organic Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0003-4493-1547
Maciej BaradynDepartment of Physical Chemistry, Institute of Chemistry, University of Bialystok, 15-245 Bialystok, Poland.
Artur RatkiewiczDepartment of Physical Chemistry, Institute of Chemistry, University of Bialystok, 15-245 Bialystok, Poland.ORCID 0000-0003-1657-1871
Danuta DrozdowskaDepartment of Organic Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.ORCID 0000-0002-3479-0480
Medical University of Białystok · PLUniversity of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eighteen previously undescribed trimethoprim (TMP) analogs containing amide bonds (

Indexed as

Folic Acid AntagonistsMolecular Docking SimulationMolecular Dynamics SimulationTrimethoprimFolic Acid AntagonistsTrimethoprimDHFR inhibitorsdrug designMGBAsmolecular dynamicsnetropsintrimethoprim

Identifiers

PMID33916202
PMCPMC8037161
OpenAlexW3148009643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.