Evidence map›Paper›PMID 33916153›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

A Rapid Screening Program for Histoplasmosis, Tuberculosis, and Cryptococcosis Reduces Mortality in HIV Patients from Guatemala.

Narda Medina, Ana Alastruey-Izquierdo, Oscar Bonilla, Osmar Gamboa, Danicela Mercado, Juan C Pérez, Luis Roberto Salazar, Eduardo Arathoon, David W Denning, Juan Luis Rodriguez-Tudela

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Predictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.Revista panamericana de salud publica = Pan American journal of public health · 2026
    Article
  7. Usefulness of Serum as a Non-Invasive Sample for the Detection ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Predictors of mortality among individuals with advanced HIV disease in a contemporary Brazilian cohort.Revista panamericana de salud publica = Pan American journal of public health · 2025
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Open forum infectious diseases · 2023
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Narda MedinaMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain.ORCID 0000-0001-6176-0052
Ana Alastruey-IzquierdoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain.ORCID 0000-0001-8651-4405
Oscar BonillaClínica Familiar "Luis Ángel García"/Hospital General San Juan de Dios, 01001 Guatemala City, Guatemala.
Osmar GamboaAsociación de Salud Integral, 01001 Guatemala City, Guatemala.ORCID 0000-0001-7409-1388
Danicela MercadoClínica Familiar "Luis Ángel García"/Hospital General San Juan de Dios, 01001 Guatemala City, Guatemala.
Juan C PérezClínica Familiar "Luis Ángel García"/Hospital General San Juan de Dios, 01001 Guatemala City, Guatemala.
Luis Roberto SalazarAsociación de Salud Integral, 01001 Guatemala City, Guatemala.ORCID 0000-0001-7836-4136
Eduardo ArathoonAsociación de Salud Integral, 01001 Guatemala City, Guatemala.ORCID 0000-0002-6225-7413
David W DenningThe National Aspergillosis Centre, University Hospital of South Manchester, Manchester M23 9LT, UK.ORCID 0000-0001-5626-2251
Juan Luis Rodriguez-TudelaGlobal Action Fund for Fungal Infections, 1208 Geneva, Switzerland.
Hospital General San Juan de Dios · GTGlobal Fund to Fight AIDS, Tuberculosis and Malaria · CHInstituto de Salud Carlos III · ESUnidad de Cirugía Cardiovascular de Guatemala · GT

Funding

Global Action Fund for Fungal infections and JYLAG Foundation E.A. received this funding under the proposal: "Minimising HIV deaths through rapid fungal diagnosis and better care in Guatemala"
6 · The paper itself

Abstract

Opportunistic infections (OIs) and advanced HIV disease (AHD) contribute to HIV-related mortality. Here, we analyzed the situation of AHD and OIs in a cohort of newly diagnosed HIV patients from Guatemala. We included 2127 adult patients from 13 facilities across the country during 2017 to 2018. Patients were screened for tuberculosis (TB), nontuberculous mycobacteria (NTM), histoplasmosis, and cryptococcal disease, independently of their CD4 cell count. Of the 2127 enrolled patients, 1682 (79.1%) had a CD4 cell count available; of which 52% presented with AHD. Of the Mayan population, 65% had AHD. The overall OI incidence was 21%. Histoplasmosis was the most frequent OI (7.9%), followed by TB (7.1%); 94.4% of these infections occurred in patients with a CD4 < 350 cells/mm

Indexed as

cryptococcosishistoplasmosislaboratory diagnosisopportunistic infectionstuberculosis

Identifiers

PMID33916153
PMCPMC8065950
OpenAlexW3143925158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.