Evidence map›Paper›PMID 33916140›Full record

ArticleCells2021

Extracellular Vesicles from Infected Cells Are Released Prior to Virion Release.

Yuriy Kim, Gifty A Mensah, Sarah Al Sharif, Daniel O Pinto, Heather Branscome, Sowmya V Yelamanchili, Maria Cowen, James Erickson, Pooja Khatkar, Renaud Mahieux and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

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  19. Tetraspanins: Host Factors in Viral Infections.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yuriy KimLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.ORCID 0000-0001-8658-6863
Gifty A MensahLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Sarah Al SharifLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Daniel O PintoLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.ORCID 0000-0002-1716-0217
Heather BranscomeLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Sowmya V YelamanchiliDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-1530-0527
Maria CowenLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
James EricksonLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Pooja KhatkarLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
Renaud MahieuxInternational Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111-Université Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Université de Lyon, Fondation Pour La Recherche Médicale, Labex Ecofect, 69007 Lyon, France.ORCID 0000-0002-5129-6804
Fatah KashanchiLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.ORCID 0000-0001-9681-2780
George Mason University · USUniversité Claude Bernard Lyon 1 · FRUniversity of Nebraska Medical Center · US

Funding

HIV neuropathogenesis related to exosomes containing HIV non-coding RNAsR01NS099029 · NINDS · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2016 to 2020
$1.9M
Role of extracellular vesicles in methamphetamine and HIV induced neurotoxicityR21DA046855 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KASHANCHI, FATAH, YELAMANCHILI, SOWMYA · 2018 to 2019
$436k
HIV-1 TAR derived miRNA: Implications for Latency and PathogenesisR21AI078859 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KASHANCHI, FATAH · 2009 to 2010
$400k
NIAID NIH HHS R21 AI078859NIDA NIH HHS R21 DA046855NIH HHS AI043894NIH HHS AI074410NIH HHS AI078859NIH HHS AI127351-01NIH HHS NS099029NINDS NIH HHS R01 NS099029
6 · The paper itself

Abstract

Here, we have attempted to address the timing of EV and virion release from virally infected cells. Uninfected (CEM), HIV-1-infected (J1.1), and human T cell leukemia virus-1 (HTLV-1)-infected (HUT102) cells were synchronized in G

Indexed as

ApoptosisBiomarkersCell LineCulture Media, ConditionedCytokinesExtracellular VesiclesHIV-1HIV InfectionsHTLV-I InfectionsHumansHuman T-lymphotropic virus 1Models, BiologicalMyeloid CellsRNA, ViralT-LymphocytesVirionBiomarkersCulture Media, ConditionedCytokinesRNA, ViralcARTexosomesextracellular vesiclesHIV-1HTLV-1

Identifiers

PMID33916140
PMCPMC8066806
OpenAlexW3151058235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.