ArticleJournal of clinical medicine2021
Changes in Neutrophil-Lymphocyte or Platelet-Lymphocyte Ratios and Their Associations with Clinical Outcomes in Idiopathic Pulmonary Fibrosis.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double-Blind, Placebo Controlled, Phase 3, Three-Arm Study of the Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
A Randomized, Double-Blind, Placebo Controlled, Phase 3 Study of the Safety and Efficacy of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis
A Randomized, Double-Blind, Placebo Controlled, Phase 3 Study of the Efficacy and Safety of Pirfenidone in Patients With Idiopathic Pulmonary Fibrosis (ASCEND Trial)
Who cites it
21 citing papers in PubMed.
- Relationship of prognostic nutritional index with clinical outcomes and survival in idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2026Article
- Inflammatory biomarkers and 30-day thoracic outcomes after surgical versus non-surgical management of spontaneous pneumothorax: a retrospective cohort study.Frontiers in medicine · 2026Article
- Association of inflammatory markers and surgical intervention with postoperative pneumonia in patients with femoral intertrochanteric fracture: A propensity score-matched cohort study.Journal of orthopaedics · 2025Article
- A Simple Ratio in a Complex Disease: Exploring the Neutrophil-to-Lymphocyte Ratio in Idiopathic Pulmonary Fibrosis.Journal of clinical medicine · 2025Review
- Article
- Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis.ERJ open research · 2024Article
- Predictive factors of mortality in patients with idiopathic pulmonary fibrosis treated with antifibrotics: a novel prognostic scoring system.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Article
- Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study.BMJ open respiratory research · 2023Article
- Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune inflammation index (SII) to predict postoperative pneumonia in elderly hip fracture patients.Journal of orthopaedic surgery and research · 2023Article
- Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers.International journal of molecular sciences · 2023Review
- The diagnostic value of the systemic immune-inflammatory index in acute appendicitis cases in the emergency department.Langenbeck's archives of surgery · 2023Article
- The Impact of Lung Cancer in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE).Journal of clinical medicine · 2023Article
- Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis.EClinicalMedicine · 2023Article
- Analysis of Clinical Characteristics of Connective Tissue Disease-Associated Interstitial Lung Disease in 161 Patients: A Retrospective Study.International journal of general medicine · 2022Article
- Genes related to N6-methyladenosine in the diagnosis and prognosis of idiopathic pulmonary fibrosis.Frontiers in genetics · 2022Article
- Prognostic Role of NLR, PLR and MHR in Patients With Idiopathic Pulmonary Fibrosis.Frontiers in immunology · 2022Article
- Changes in Neutrophil-Lymphocyte or Platelet-Lymphocyte Ratios and Their Associations with Clinical Outcomes in Idiopathic Pulmonary Fibrosis.Journal of clinical medicine · 2021Article
- Systemic Immune-Inflammation Index (SII) Can Be an Early Indicator for Predicting the Severity of Acute Pancreatitis: A Retrospective Study.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Identification of prognostic and predictive biomarkers in idiopathic pulmonary fibrosis (IPF) could aid assessment of disease severity and prediction of progression and response to treatment. This analysis examined reference ranges for neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in IPF, and the relationship between NLR or PLR changes and clinical outcomes over 12 months. This post hoc analysis included patients with IPF from the Phase III, double-blind trials of pirfenidone, ASCEND (NCT01366209) and CAPACITY (NCT00287716 and NCT00287729). The relationship between change from baseline to Month 12 in NLR or PLR (divided into quartiles (Q1-Q4)) and outcomes (mortality, respiratory hospitalization, declines in lung function, exercise capacity and quality of life) was assessed. Estimated reference ranges at baseline for all patients analyzed (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.