Evidence map›Paper›PMID 33916020›Full record

ArticleJournal of clinical medicine2021

Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic.

Abanoub Riad, Andrea Pokorná, Sameh Attia, Jitka Klugarová, Michal Koščík, Miloslav Klugar

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04834869 (COVID-19 Vaccines Safety Tracking), which is not on this map. Cited by 205 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04834869 recruitingnot on this map

COVID-19 Vaccines Safety Tracking: Global Consortium Study

TypeobservationalSponsorMasaryk UniversityRan2021 to 2026Enrolled30,000ConditionsAdverse Reaction to Vaccine, COVID19 VaccineArmsBNT162b2, mRNA-1273, AZD1222, CoronaVac, Sinopharm
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abanoub RiadDepartment of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0001-5918-8966
Andrea PokornáCzech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0002-1305-6455
Sameh AttiaDepartment of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.ORCID 0000-0002-9174-6435
Jitka KlugarováDepartment of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Michal KoščíkDepartment of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Miloslav KlugarDepartment of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0002-2804-7295

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/16_013/0001826Masarykova Univerzita MUNI/A/1608/2020Masarykova Univerzita MUNI/IGA/1543/2020Ministerstvo Školství, Mládeže a Tělovýchovy LM2018128Ministerstvo Školství, Mládeže a Tělovýchovy LTC20031
6 · The paper itself

Abstract

backgroundCOVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer-BioNTech COVID-19 vaccine side effects.

methodsA cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants' demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects.

resultsInjection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects.

conclusionsThe distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer's data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer's report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine.

Indexed as

adverse effectsBNT162 vaccineCOVID-19cross-sectional studiesCzech Republicdrug-related side effects and adverse reactionshealth personnelmass vaccinationprevalence

Identifiers

PMID33916020
PMCPMC8037149

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.