ReviewMolecules (Basel, Switzerland)2021
Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05999175 (Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control), which is not on this map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Effectiveness of Mouthwash, Rinses, Salt Water, and Toothpastes on the Oral Health of Pregnant Women: A Systematic Review: Pregnancy and Oral Health.Global health, epidemiology and genomics · 2026Pooled it
- The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic treatment: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Efficacy of toothpaste containing OPTIMEALTH® OR in inhibiting dental plaque and gingivitis: A randomized controlled trial.Medicine · 2025Trial
- Pilot randomized trial of the effect of antibacterial mouthwash on muscle contractile function in healthy young adults.PloS one · 2025Trial
- The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Randomised-crossover clinical trial on the substantivity of a single application of a gel containing chlorhexidine and o-cymen-5-ol on the oral biofilm and saliva.BMC oral health · 2024Trial
- Efficacy and Tolerability of aNutrients · 2024Trial
- Effects of hypochlorous acid mouthwash on salivary bacteria including Staphylococcus aureus in patients with periodontal disease: a randomized controlled trial.BMC oral health · 2023Trial
- Enzymatic tools for the treatment of caries-associated biofilms: Investigating the enzymes of a putative polysaccharide utilization locus from Prevotella melaninogenica and their application against Streptococcus mutans biofilm.World journal of microbiology & biotechnology · 2026Article
- The Role of Herbal Medicine in the Management of Oral Conditions: A Comprehensive Review.Journal of dentistry (Shiraz, Iran) · 2026Review
- New Insights into the Antimicrobial and Wound-Healing Properties of Turmeric-Powder-DerivedBiomedicines · 2026Article
- Effects of a New Combination of Antibiofilm Enzymes, Antiadhesive Agents, and Liquorice Extracts on Plaque Accumulation in Dogs: An Unicenter, Controlled, and Randomized Study.Journal of veterinary dentistry · 2026Article
- The Inhibition of Streptococcus mutans Biofilms following Exposure to Different Chocolate Ingredients.European journal of dentistry · 2026Article
- Impact of Antimicrobial Mouthwash on Outcomes of Er: YAG Laser Versus Scalpel Frenectomy: A Retrospective Longitudinal Cohort Study.Journal of clinical medicine · 2026Article
- Green synthesis of silver-coated zinc oxide nanocomposite using the walnut green husk extract and assessment of its cytotoxicity and antimicrobial activity againstAvicenna journal of phytomedicine · 2026Article
- Development of Herbal Mouthwash Powder Using a Self-Nanoemulsifying Drug Delivery System Containing Galangal Extract and Lemongrass Oil for Oral Candidiasis Treatment.Pharmaceutics · 2025Article
- Sodium fluoride promotes myopia progression via the activation of the ferroptosis pathway by PIEZO1 and pharmacological targeting PIEZO1 represents an innovative approach for myopia treatment.Cell biology and toxicology · 2025Article
- Comparing In Vitro Virucidal Efficacy of Commercially Available Mouthwashes Against Native High-Risk Human Papillomavirus Types 16 and 18.Microorganisms · 2025Article
- In vitro analysis of various mouthwashes: cytotoxic, apoptotic, genotoxic and antibacterial effects.Clinical oral investigations · 2025Article
- Green Tea: A Novel Perspective on the Traditional Plant's Potential in Managing Periodontal Diseases.Pharmaceuticals (Basel, Switzerland) · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal diseases like gingivitis and periodontitis are primarily caused by dental plaque. Several antiplaque and anti-microbial agents have been successfully incorporated into toothpastes and mouthwashes to control plaque biofilms and to prevent and treat gingivitis and periodontitis. The aim of this article was to review recent developments in the antiplaque, anti-gingivitis, and anti-periodontitis properties of some common compounds in toothpastes and mouthwashes by evaluating basic and clinical studies, especially the ones published in the past five years. The common active ingredients in toothpastes and mouthwashes included in this review are chlorhexidine, cetylpyridinium chloride, sodium fluoride, stannous fluoride, stannous chloride, zinc oxide, zinc chloride, and two herbs-licorice and curcumin. We believe this comprehensive review will provide useful up-to-date information for dental care professionals and the general public regarding the major oral care products on the market that are in daily use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.