Evidence map›Paper›PMID 33916009›Full record

ArticleVaccines2021

Transcriptome of Tumor-Infiltrating T Cells in Colorectal Cancer Patients Uncovered a Unique Gene Signature in CD4

Salman M Toor, Varun Sasidharan Nair, Reem Saleh, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Ayman A Ahmed, Mohamed A Kurer, Mohamed Abu Nada and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. CD4Trends in cancer · 2024
    Review
  2. Article
  3. Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment.Journal of experimental & clinical cancer research : CR · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Salman M ToorCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box 34110 Doha, Qatar.ORCID 0000-0002-4683-3329
Varun Sasidharan NairCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box 34110 Doha, Qatar.
Reem SalehCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box 34110 Doha, Qatar.
Rowaida Z TahaCancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box 34110 Doha, Qatar.ORCID 0000-0001-6119-8389
Khaled MurshedDepartment of Pathology, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.ORCID 0000-0001-8045-363X
Mahmood Al-DhaheriDepartment of Surgery, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.
Mahwish KhawarDepartment of Surgery, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.
Ayman A AhmedDepartment of Surgery, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.
Mohamed A KurerDepartment of Surgery, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.
Mohamed Abu NadaDepartment of Surgery, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar.
Eyad ElkordBiomedical Research Center, School of Science, Engineering and Environment, University of Salford, Manchester M5 4WT, UK.ORCID 0000-0002-3868-0318
Hamad Medical Corporation · QAHamad bin Khalifa University · QAUniversity of Salford · GB

Funding

Qatar Foundation VR04
6 · The paper itself

Abstract

Colorectal cancer (CRC) is influenced by infiltration of immune cell populations in the tumor microenvironment. While elevated levels of cytotoxic T cells are associated with improved prognosis, limited studies have reported associations between CD4

Indexed as

colorectal cancerT cellstranscriptomicstumor microenvironment

Identifiers

PMID33916009
PMCPMC8065799
OpenAlexW3140663476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.