Evidence map›Paper›PMID 33915984›Full record

ArticleCells2021

Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination.

Jun Liu, Xiaojing Hong, Lihui Wang, Chao-Ya Liang, Jun-Ping Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. The landscape of aging.Science China. Life sciences · 2022
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jun LiuInstitute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-9565-5207
Xiaojing HongInstitute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Lihui WangInstitute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Chao-Ya LiangInstitute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.
Jun-Ping LiuInstitute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0001-7442-2116
Hangzhou Normal University · CN

Funding

China Postdoctoral Science Foundation 2014M551470National Key Research and Development Program of China 2018YFC2000100National Natural Science Foundation of China 31501110National Natural Science Foundation of China 81530039Postdoctoral Research Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014KIP305Start-up Research Program of Hangzhou Normal University 2018QDL010
6 · The paper itself

Abstract

Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast

Indexed as

Cellular SenescenceGene DeletionModels, BiologicalRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeTelomereTelomere HomeostasisSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR4 protein, S cerevisiaecell senescenceRif1senescence regulationSir4sub-telomerestelomere binding proteinyeast

Identifiers

PMID33915984
PMCPMC8066019
OpenAlexW3143591679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.