ReviewInsects2021
The Insect Type 1 Tyramine Receptors: From Structure to Behavior.
Review in Insects, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting the Type 1 Tyramine ReceptorInsects · 2026Article
- CaActa physiologica (Oxford, England) · 2025Article
- Octopamine modulates the innate immune response inFrontiers in immunology · 2025Article
- Tyramine-Mediated Hyperactivity Modulates the Dietary Habits in Helicoverpa armigera.Journal of chemical ecology · 2024Article
- Octopamine in the mushroom body circuitry for learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Octopamine is required for successful reproduction in the classical insect model, Rhodnius prolixus.PloS one · 2024Article
- Using machine learning to predict protein-protein interactions between a zombie ant fungus and its carpenter ant host.Scientific reports · 2023Article
- Specificity of Monoterpene Interactions with Insect Octopamine and Tyramine Receptors: Insights fromACS omega · 2023Article
- Secondary Metabolites in Nectar-Mediated Plant-Pollinator Relationships.Plants (Basel, Switzerland) · 2023Review
- Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles.PloS one · 2023Article
- Ionizing radiation alters functional neurotransmission inFrontiers in cellular neuroscience · 2023Article
- The octopamine receptor OAα1 influences oogenesis and reproductive performance in Rhodnius prolixus.PloS one · 2023Article
- Behavioral roles of biogenic amines in bumble bee males.Scientific reports · 2022Article
- Article
- Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp,Insects · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyramine is a neuroactive compound that acts as neurotransmitter, neuromodulator, and neurohormone in insects. Three G protein-coupled receptors, TAR1-3, are responsible for mediating the intracellular pathway in the complex tyraminergic network. TAR1, the prominent player in this system, was initially classified as an octopamine receptor which can also be activated by tyramine, while it later appeared to be a true tyramine receptor. Even though TAR1 is currently considered as a well-defined tyramine receptor and several insect TAR1s have been characterized, a defined nomenclature is still inconsistent. In the last years, our knowledge on the structural, biochemical, and functional properties of TAR1 has substantially increased. This review summarizes the available information on TAR1 from different insect species in terms of basic structure, its regulation and signal transduction mechanisms, and its distribution and functions in the brain and the periphery. A special focus is given to the TAR1-mediated intracellular signaling pathways as well as to their physiological role in regulating behavioral traits. Therefore, this work aims to correlate, for the first time, the physiological relevance of TAR1 functions with the tyraminergic system in insects. In addition, pharmacological studies have shed light on compounds with insecticidal properties having TAR1 as a target and on the emerging trend in the development of novel strategies for pest control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.