Evidence map›Paper›PMID 33915968›Full record

ArticleMolecules (Basel, Switzerland)2021

Deciphering the Interactions of Bioactive Compounds in Selected Traditional Medicinal Plants against Alzheimer's Diseases via Pharmacophore Modeling, Auto-QSAR, and Molecular Docking Approaches.

Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Charles Okolie, Mary-Ann Chinyere Nwakama, Matthew Iyobhebhe, Ikponmwosa Owen Evbuomwan, Charles Obiora Nwonuma, Rotdelmwa Filibus Maimako, Abayomi Emmanuel Adegboyega, Odunayo Anthonia Taiwo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
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  3. Structural Bioinformatics Applied to Acetylcholinesterase Enzyme Inhibition.International journal of molecular sciences · 2025
    Review
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  9. Study ofMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Oluwafemi Adeleke OjoMedicinal Biochemistry and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu-Aran PMB 1001, Nigeria.ORCID 0000-0001-9331-396X
Adebola Busola OjoDepartment of Biochemistry, Faculty of Sciences, Ekiti State University, Ado-Ekiti PMB 5363, Nigeria.ORCID 0000-0003-1421-3819
Charles OkolieDepartment of Microbiology, Landmark University, Omu-Aran PMB 1001, Nigeria.
Mary-Ann Chinyere NwakamaMedicinal Biochemistry and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu-Aran PMB 1001, Nigeria.
Matthew IyobhebheMedicinal Biochemistry and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu-Aran PMB 1001, Nigeria.ORCID 0000-0001-5198-1441
Ikponmwosa Owen EvbuomwanDepartment of Microbiology, Landmark University, Omu-Aran PMB 1001, Nigeria.
Charles Obiora NwonumaMedicinal Biochemistry and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu-Aran PMB 1001, Nigeria.
Rotdelmwa Filibus MaimakoMedicinal Biochemistry and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu-Aran PMB 1001, Nigeria.
Abayomi Emmanuel AdegboyegaDepartment of Biochemistry, Faculty of Basic Medical Science, University of Jos, Jos PMB 2084, Nigeria.ORCID 0000-0003-1349-9966
Odunayo Anthonia TaiwoDepartment of Biochemistry, Chrisland University, Abeokuta PMB 2131, Nigeria.ORCID 0000-0001-8752-3290
Khalaf F AlsharifDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira 22511, Egypt.ORCID 0000-0002-7817-425X
Landmark University · NGDamanhour University · EGEkiti State University · NGTaif University · SAUniversity of Jos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases, for example Alzheimer's, are perceived as driven by hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, for example flavonoids, are documented in studies for having the ability to pass the blood-brain barrier and moderate the development of such illnesses. Computer-aided drug design (CADD) has achieved importance in the drug discovery world; innovative developments in the aspects of structure identification and characterization, bio-computational science, and molecular biology have added to the preparation of new medications towards these ailments. In this study we evaluated nine flavonoid compounds identified from three medicinal plants, namely

Indexed as

Drug DiscoveryMolecular Docking SimulationMolecular Dynamics SimulationQuantitative Structure-Activity RelationshipAcetylcholinesteraseAlzheimer DiseaseBinding SitesButyrylcholinesteraseCholinesterase InhibitorsHumansLigandsMolecular ConformationMolecular StructurePhytochemicalsPlants, MedicinalProtein BindingAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsLigandsPhytochemicalsAlzheimer’sbioactive compoundsmolecular dockingneurodegenerative diseasespharmacophore modelingQSAR

Identifiers

PMID33915968
PMCPMC8037217
OpenAlexW3148392921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.