Evidence map›Paper›PMID 33915937›Full record

ArticleInternational journal of environmental research and public health2021

Mild to Severe Neurological Manifestations of COVID-19: Cases Reports.

Gabriele Melegari, Veronica Rivi, Gabriele Zelent, Vincenzo Nasillo, Elena De Santis, Alessandra Melegari, Claudia Bevilacqua, Michele Zoli, Stefano Meletti, Alberto Barbieri

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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  14. Post-acute COVID-19 functional movement disorder.SAGE open medical case reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gabriele MelegariAnaesthesia and Intensive Care, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.
Veronica RiviDepartment of Biomedical, Metabolic and Neural Sciences, Neuroscience Post Graduate School, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-8413-4510
Gabriele ZelentNeuroradiology, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.
Vincenzo NasilloDepartment of Laboratory Medicine, Azienda Unità Sanitaria Locale, 41125 Modena, Italy.ORCID 0000-0001-5122-5574
Elena De SantisDepartment of Laboratory Medicine, Azienda Unità Sanitaria Locale, 41125 Modena, Italy.
Alessandra MelegariDepartment of Laboratory Medicine, Azienda Unità Sanitaria Locale, 41125 Modena, Italy.
Claudia BevilacquaSchool of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Michele ZoliDepartment of Biomedical, Metabolic and Neural Sciences, Neuroscience Post Graduate School, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Stefano MelettiNeurology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0003-0334-539X
Alberto BarbieriSchool of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, 41125 Modena, Italy.
University of Modena and Reggio Emilia · ITAzienda Ospedaliero-Universitaria di Modena · ITAzienda Unita' Sanitaria Locale Di Modena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main focus of Coronavirus disease 2019 (COVID-19) infection is pulmonary complications through virus-related neurological manifestations, ranging from mild to severe, such as encephalitis, cerebral thrombosis, neurocognitive (dementia-like) syndrome, and delirium. The hospital screening procedures for quickly recognizing neurological manifestations of COVID-19 are often complicated by other coexisting symptoms and can be obscured by the deep sedation procedures required for critically ill patients. Here, we present two different case-reports of COVID-19 patients, describing neurological complications, diagnostic imaging such as olfactory bulb damage (a mild and unclear underestimated complication) and a severe and sudden thrombotic stroke complicated with hemorrhage with a low-level cytokine storm and respiratory symptom resolution. We discuss the possible mechanisms of virus entrance, together with the causes of COVID-19-related encephalitis, olfactory bulb damage, ischemic stroke, and intracranial hemorrhage.

Indexed as

COVID-19Nervous System DiseasesStrokeHumansIntracranial HemorrhagesSARS-CoV-2anosmiaCOVID-19 outbreakencephalitis thrombosisintensive care unit

Identifiers

PMID33915937
PMCPMC8036948
OpenAlexW3147583493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.