Evidence map›Paper›PMID 33915768›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Development of a Rapid UHPLC-PDA Method for the Simultaneous Quantification of Flavonol Contents in Onions (

Ana V González-de-Peredo, Mercedes Vázquez-Espinosa, Ceferino Carrera, Estrella Espada-Bellido, Marta Ferreiro-González, Gerardo F Barbero, Miguel Palma

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. On the Valorization ofFoods (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
  5. Quercetin-Rich Extracts from Onions (Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana V González-de-PeredoDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0002-0161-3533
Mercedes Vázquez-EspinosaDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0002-7254-9153
Ceferino CarreraDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0002-6835-8303
Estrella Espada-BellidoDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0002-8166-2510
Marta Ferreiro-GonzálezDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0003-0870-403X
Gerardo F BarberoDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0001-7302-6605
Miguel PalmaDepartment of Analytical Chemistry, Faculty of Sciences, Agrifood Campus of International Excellence (ceiA3), University of Cadiz, IVAGRO, Puerto Real, 11510 Cadiz, Spain.ORCID 0000-0001-8509-4226

Funding

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria RTA2014-00083-C03-03Ministerio de Ciencia e Innovación AP-2018-03811State Subprogram of Research Infrastructures and Technical Scientific Equipment EQC2018-005135-P
6 · The paper itself

Abstract

Onion, one of the most consumed vegetables in the world, is also known to contain high levels of antioxidant compounds, with protective effects against different degenerative pathologies. Specifically, onion is rich in flavonols, mainly quercetin derivatives, which are compounds with high antioxidant and free radical scavenging power. For this reason, it is of the utmost importance to count on optimal analytical methods that allow for the determination and quantification of these compounds of interest. A rapid ultra-high performance liquid chromatography (UHPLC)-photo-diode array (PDA) method for the separation of the major flavonols in onions was developed using a Box-Behnken design in conjunction with multiresponse optimization on the basis of the desirability function. The conditions that provided a successful separation were 9.9% and 53.2% of phase B at the beginning and at the end of the gradient, respectively; 55 °C column working temperature; and 0.6 mL min

Indexed as

Allium cepa L.Box–Behnkenflavonoidsliquid chromatographymultiresponse optimizationonionphenolic compoundsquercetin glycosidesUHPLC

Identifiers

PMID33915768
PMCPMC8066725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.