Evidence map›Paper›PMID 33915763›Full record

ArticleVaccines2021

Persistence of Anti-Hbs after up to 30 Years in Health Care Workers Vaccinated against Hepatitis B Virus.

Silvia Cocchio, Vincenzo Baldo, Anna Volpin, Marco Fonzo, Annarosa Floreani, Patrizia Furlan, Paola Mason, Andrea Trevisan, Maria Luisa Scapellato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Systemic Inflammation and the Persistence of Vaccine-Induced Hepatitis B Immunity in Healthcare Workers.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Observational
  2. Review
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  18. Hepatitis B immunisation and immune status of nurses in a regional hospital in central South Africa.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Silvia CocchioDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.
Vincenzo BaldoDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.ORCID 0000-0001-6012-9453
Anna VolpinDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.
Marco FonzoDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.ORCID 0000-0002-9561-0711
Annarosa FloreaniScientific Institute for Research, Hospitalization and Healthcare Negrar, 37024 Negrar, Italy.
Patrizia FurlanDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.
Paola MasonDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.
Andrea TrevisanDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.ORCID 0000-0002-0764-1084
Maria Luisa ScapellatoDepartment of Cardiac Thoracic and Vascular Sciences, and Public Health, University of Padua, 35100 Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The burden of hepatitis B virus (HBV) infection is a serious public health problem all over the world. Vaccination remains the most effective prevention measure, and safe and effective HBV vaccines have been available since 1982. Health care workers (HCWs) vaccinated against HBV and prospectively followed up for at least 14 years were classified by their antibody titers after primary vaccination as: poor responders (10-99 mIU/mL); moderate responders (100-999 mIU/mL); and good responders (≥1000 mIU/mL). The incidence of antibody loss was calculated for 1000 person-years and the anti-HBs persistence was calculated. The analysis concerned 539 HCWs: 494 good responders (91.7%); 37 moderate responders (6.9%); and eight poor responders (1.5%). The incidence of anti-HBs loss was 52.1 per 1000 person-years for the poor responders, 11.3 per 1000 person-years for the moderate responders, and 1.4 per 1000 person-years for the good responders. The mean persistence of anti-HBs differed significantly between the three groups, being: 19.2 years (95% CI: 15.6-22.8), 25.4 years (95% CI: 23.0-27.9), and 31.0 years (95% CI: 30.5-31.5) for the poor, moderate and good responders, respectively. In conclusion, our findings demonstrate a good persistence of protective anti-HBs titers in HCWs exposed to occupational risk for up to 30 years after a primary vaccination cycle (even without a booster dose) if their titer was initially higher than 100 mIU/mL.

Indexed as

anti-HBsHBVhealth care workersvaccination

Identifiers

PMID33915763
PMCPMC8067181
OpenAlexW3142206966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.