ArticleClinical endoscopy2021
Clinical Features and Predictors of Dysplasia in Proximal Sessile Serrated Lesions.
Article in Clinical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Prevalence and characteristics of sessile serrated lesions with dysplasia in Dutch fecal immunochemical test-positive screenees.Endoscopy · 2026Article
- Distinguishing colorectal sessile serrated lesions from hyperplastic polyps: development of a prediction model based on logistic regression.BMC gastroenterology · 2026Article
- Histologic Reappraisal and Evaluation of MLH1 Protein Expression in Sessile Serrated Lesions of the Proximal Colon.Gastroenterology research and practice · 2025Article
- Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 revised edition.Intestinal research · 2023Review
- Impact of looping on premalignant polyp detection during colonoscopy.World journal of gastrointestinal endoscopy · 2022Article
- Korean guidelines for postpolypectomy colonoscopic surveillance: 2022 revised edition.Clinical endoscopy · 2022Review
- [Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 Revised Edition].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsProximal colorectal cancers (CRCs) account for up to half of CRCs. Sessile serrated lesions (SSLs) are precursors to CRC. Proximal location and presence of dysplasia in SSLs predict higher risks of progression to cancer. The prevalence of dysplasia in proximal SSLs (pSSLs) and clinical characteristics of dysplastic pSSLs are not well studied.
methodsEndoscopically resected colonic polyps at our center between January 2016 and December 2017 were screened for pSSLs. Data of patients with at least one pSSL were retrieved and clinicopathological features of pSSLs were analysed. pSSLs with and without dysplasia were compared for associations.
resultsNinety pSSLs were identified, 45 of which had dysplasia giving a prevalence of 50.0%. Older age (65.9 years vs. 60.1 years, p=0.034) was associated with the presence of dysplasia. Twelve pSSLs were 10 mm or larger. After adjusting for age, pSSLs ≥10 mm had an adjusted odds ratio of 5.98 (95% confidence interval, 1.21-29.6) of having dysplasia compared with smaller pSSLs.
conclusionIn our cohort of pSSLs, the prevalence of dysplasia is high at 50.0% and is associated with lesion size ≥10 mm. Endoscopic resection for all proximal serrated lesions should be en-bloc to facilitate accurate histopathological examination for dysplasia as its presence warrants shorter surveillance intervals.
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