ArticleOsteoarthritis and cartilage2021
Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis.
Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Exercise-myokine relationships in osteoarthritis.Journal of translational medicine · 2026Review
- Integrating machine learning with SHAP to uncover multi-tissue molecular signatures in Osteoarthritis progression.PloS one · 2026Article
- Circulating Aggrecan, Biglycan, and Decorin as Biomarkers of Osteoarticular Alterations in Juvenile Idiopathic Arthritis-A Preliminary Study.International journal of molecular sciences · 2025Article
- Review
- Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan Integration.bioRxiv : the preprint server for biology · 2025Article
- Metabolic crosstalk between skeletal muscle and cartilage tissue: insights into myokines in osteoarthritis.Molecular biology reports · 2025Review
- Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Recombinant Small Leucine-Rich Proteoglycans Modulate Fiber Structure and Mechanical Properties of Collagen Gels.ACS biomaterials science & engineering · 2025Article
- Key roles of the superficial zone in articular cartilage physiology, pathology, and regeneration.Chinese medical journal · 2025Review
- Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness.Bone research · 2025Article
- RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.Communications biology · 2024Article
- Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage.ACS biomaterials science & engineering · 2024Article
- Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development.Bone research · 2024Article
- The role of vitamin D receptor in predentin mineralization and dental repair after injury.Cell and tissue research · 2024Article
- The shared molecular mechanism of spinal cord injury and sarcopenia: a comprehensive genomics analysis.Frontiers in neurology · 2024Article
- Proteoglycans in Articular Cartilage and Their Contribution to Chondral Injury and Repair Mechanisms.International journal of molecular sciences · 2023Review
- Salivary biglycan-neo-epitope-BGNOsteoarthritis and cartilage open · 2023Article
- BMSCs-derived Mitochondria Improve Osteoarthritis by Ameliorating Mitochondrial Dysfunction and Promoting Mitochondrial Biogenesis in Chondrocytes.Stem cell reviews and reports · 2022Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo delineate the activities of decorin and biglycan in the progression of post-traumatic osteoarthritis (PTOA).
designThree-month-old inducible biglycan (Bgn
resultsIn the DMM model, Bgn
conclusionIn PTOA, decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.