Evidence map›Paper›PMID 33915215›Full record

ArticleBiological psychology2021

Vitamin D levels in children with attention deficit hyperactivity disorder: Association with seasonal and geographical variation, supplementation, inattention severity, and theta:beta ratio.

Melissa C Miller, Xueliang Pan, L Eugene Arnold, Arielle Mulligan, Shea Connor, Rachel Bergman, Roger deBeus, Michelle E Roley-Roberts

Open access · greenAbstract read
In one paragraph

Article in Biological psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Melissa C MillerDepartment of Psychological Sciences, Auburn University, Auburn, AL, 36849, USA; Department of Psychiatry & Behavioral Health, Ohio State University, Columbus, OH, 43210, USA; Nisonger Center UCEDD, Ohio State University, Columbus, OH, 43210, USA. Electronic address: mcm0126@auburn.edu.
Xueliang PanDepartment of Biomedical Informatics, Center for Biostatistics, Ohio State University, Columbus, OH, 43210, USA. Electronic address: Jeff.Pan@osumc.edu.
L Eugene ArnoldDepartment of Psychiatry & Behavioral Health, Ohio State University, Columbus, OH, 43210, USA; Nisonger Center UCEDD, Ohio State University, Columbus, OH, 43210, USA. Electronic address: L.Arnold@osumc.edu.
Arielle MulliganDepartment of Psychiatry & Behavioral Health, Ohio State University, Columbus, OH, 43210, USA; Nisonger Center UCEDD, Ohio State University, Columbus, OH, 43210, USA. Electronic address: Arielle.Mulligan@osumc.edu.
Shea ConnorDepartment of Psychology, University of North Carolina at Asheville, Asheville, NC, 28804, USA. Electronic address: sconnor@unca.edu.
Rachel BergmanDepartment of Psychiatry & Behavioral Health, Ohio State University, Columbus, OH, 43210, USA; Nisonger Center UCEDD, Ohio State University, Columbus, OH, 43210, USA. Electronic address: Bergman.138@buckeyemail.osu.edu.
Roger deBeusDepartment of Psychology, University of North Carolina at Asheville, Asheville, NC, 28804, USA. Electronic address: Roger.deBeus@gmail.com.
Michelle E Roley-RobertsDepartment of Psychiatry & Behavioral Health, Ohio State University, Columbus, OH, 43210, USA; Nisonger Center UCEDD, Ohio State University, Columbus, OH, 43210, USA; Department of Psychiatry, Creighton University, 68152, USA. Electronic address: Michelle.E.Roley@gmail.com.
The Ohio State University · USInstitute for Behavioral Medicine · USUniversity of North Carolina at Asheville · USCreighton University · US

Funding

The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
Double-Blind Randomized Clinical Trial of EEG Neurofeedback for ADHDR01MH100144 · NIMH · OHIO STATE UNIVERSITY · PI ARNOLD, L EUGENE · 2014 to 2018
$3.5M
NCATS NIH HHS UL1 TR000090NIMH NIH HHS R01 MH100144
6 · The paper itself

Abstract

We examined seasonal and geographic effects on vitamin D [25(OH)D] levels, association with attention-deficit/hyperactivity disorder (ADHD) symptom severity, and effects of supplementation in 222 children age 7-10 with rigorously diagnosed ADHD. 25(OH)D insufficiency rates were 47.2 % in Ohio and 28.5 % 400 miles south in North Carolina. Nadir of 25(OH)D levels was reached by November in Ohio, not until January in NC. Thirty-eight children with insufficiency/deficiency took vitamin D (1000-2000 IU/day for a month); levels rose 52 %. Although inattention did not correlate with 25(OH)D at screen nor improve significantly with supplementation, inattention improvement after supplementation correlated with 25(OH)D increase (rho = 0.41, p = 0.012). A clinically significant proportion of children with ADHD have insufficient 25(OH)D even at summer's end, more so in the winter and north of the 37th parallel. The significant correlation of inattention improvement with 25(OH)D increase suggests further research on 25(OH)D as ADHD treatment.

Indexed as

Attention Deficit Disorder with HyperactivityChildDietary SupplementsHumansSeasonsVitamin DVitaminsVitamin DVitamins25-hydroxyvitamin DAttention-deficit/hyperactivity disorderLatitudeSeasonal variationtheta:beta ratioVitamin D

Identifiers

PMID33915215
PMCPMC8187333
OpenAlexW3158240255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.