Evidence map›Paper›PMID 33915081›Full record

ArticleCell stem cell2021

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.

Ling Huang, Ridhdhi Desai, Daniel N Conrad, Nayara C Leite, Dipikaa Akshinthala, Christine Maria Lim, Raul Gonzalez, Lakshmi B Muthuswamy, Zev Gartner, Senthil K Muthuswamy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 110 citations in OpenAlex.

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  17. Decoding cancer etiology with cellular reprogramming.Current opinion in genetics & development · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ling HuangCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Ridhdhi DesaiCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Daniel N ConradDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Nayara C LeiteDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Dipikaa AkshinthalaCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Christine Maria LimCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Raul GonzalezCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Lakshmi B MuthuswamyCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Zev GartnerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA; NSF Center for Cellular Construction, San Francisco, CA 94158, USA.
Senthil K MuthuswamyCancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: smuthusw@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USUniversity of California, San Francisco · USHarvard University · US

Funding

Stopping PDA progression using inhibitors of CSC dissemination and immunotherapyU01CA224193 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HINGORANI, SUNIL R · 2017 to 2021
$3.3M
MULTIseq: multiplexing massively parallel single cell transcriptional analysis across time, space, and conditionsR01GM135462 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN · 2019 to 2022
$1.3M
To investigate the molecular and cellular mechanisms through which KRAS and BRAF oncogenes regulate cell polarity during epithelial morphogenesisF32GM115201 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI DESAI, RIDHDHI R · 2015 to 2017
$173k
NCI NIH HHS U01 CA224193NIGMS NIH HHS F32 GM115201NIGMS NIH HHS R01 GM135462
6 · The paper itself

Abstract

The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and progression of human pancreatic diseases, including PDAC, is limited because of challenges in maintaining human acinar and ductal cells in culture. Here we report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas. Expression of the PDAC-associated oncogene GNAS

Indexed as

Carcinoma, Pancreatic DuctalPancreas, ExocrinePancreatic NeoplasmsAcinar CellsHumansInfant, NewbornOncogenesOrganoidsPancreasStem Cellsacinicancer precursorexocrine pancreasGNASKRASlineage specificationorganoidpancreatic cancerplasticitypluripotent stem cell

Identifiers

PMID33915081
PMCPMC8202734
OpenAlexW3158629111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.