Evidence map›Paper›PMID 33915063›Full record

ArticlePharmaceutical biology2021

Quantification of thonningianin a in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.

Qian Liu, Chunmin Li, Pan Zhao, Jing Li, Zhipeng Deng

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian LiuCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Chunmin LiDepartment of Pharmacy, Jinan Maternity and Child Care Hospital, Jinan, PR China.
Pan ZhaoCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Jing LiCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Zhipeng DengCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThonningianin A is an ellagitannin substance and displays multiple pharmacological activities.

objectiveThis study investigated the pharmacokinetic characteristics of thonningianin A after oral administration in rats using a fully validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method. MATERIALS AND

methodsA sensitive and selective LC-MS/MS assay was developed for quantifying thonningianin A. Eighteen Wistar rats were randomly divided into three groups (

resultsThonningianin A and internal standard (IS) were eluted at 1.5 and ∼3.0 min, respectively. The selected reaction mode transitions monitored were DISCUSSION AND

conclusionsThe present method is the first report in terms of the simple precipitation procedure, high sensitivity, and high-throughput efficiency. This validated assay was successfully applied to determine the pharmacokinetic behaviours of thonningianin A in rats. This study should be helpful for providing references for understanding the action mechanism and further application of

Indexed as

Administration, OralAnimalsChromatography, LiquidDose-Response Relationship, DrugHydrolyzable TanninsRatsRats, WistarTandem Mass SpectrometryHydrolyzable Tanninsthonningianin ALC-MS/MSliver diseasesmethod validationPenthorum chinense

Identifiers

PMID33915063
PMCPMC8871622

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Registered trials

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