Evidence map›Paper›PMID 33915002›Full record

ReviewEuropean journal of heart failure2021

Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy.

Pablo Garcia-Pavia, Frank Bengel, Dulce Brito, Thibaud Damy, Franz Duca, Sharmila Dorbala, Jose Nativi-Nicolau, Laura Obici, Claudio Rapezzi, Yoshiki Sekijima and 1 more

Abstract readReviewConsensus Statement
In one paragraph

Review in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  7. Review
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  15. Review
  16. Cardiac transthyretin amyloidosis in aortic valve replacement: RAISE score performance in the postoperative setting.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
  17. Outpatient diuretic intensification: a simple prognostic marker in cardiac transthyretin amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  18. Incremental prognostic utility of congestion markers in cardiac transthyretin amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  19. Review
  20. Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pablo Garcia-PaviaHeart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV, Madrid, Spain.
Frank BengelDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Dulce BritoHeart and Vessels Department, Centro Hospitalar Universitário de Lisboa Norte, CCUL, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Thibaud DamyEuropean Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Amsterdam, The Netherlands.
Franz DucaDepartment of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Sharmila DorbalaDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Jose Nativi-NicolauDepartment of Medicine, University of Utah Health Care, Salt Lake City, UT, USA.
Laura ObiciAmyloidosis Research and Treatment Centre, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
Claudio RapezziCardiological Centre, University of Ferrara, Ferrara, Italy.
Yoshiki SekijimaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
Perry M ElliottUniversity College London Institute for Cardiovascular Science & St Bartholomew's Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening condition with a heterogeneous clinical presentation. The recent availability of treatment for ATTR-CM has stimulated increased awareness of the disease and patient identification. Stratification of patients with ATTR-CM is critical for optimal management and treatment; however, monitoring disease progression is challenging and currently lacks best-practice guidance. In this report, experts with experience in treating amyloidosis and ATTR-CM developed consensus recommendations for monitoring the course of patients with ATTR-CM and proposed meaningful thresholds and frequency for specific parameters. A set of 11 measurable features across three separate domains were evaluated: (i) clinical and functional endpoints, (ii) biomarkers and laboratory markers, and (iii) imaging and electrocardiographic parameters. Experts recommended that one marker from each of the three domains provides the minimum requirements for assessing disease progression. Assessment of cardiac disease status should be part of a multiparametric evaluation in which progression, stability or improvement of other involved systems in transthyretin amyloidosis should also be considered. Additional data from placebo arms of clinical trials and future studies assessing ATTR-CM will help to elucidate, refine and define these and other measurements.

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesHeart FailureConsensusHumansPrealbuminPrealbuminAmyloidosisCardiac imagingHeart failureLaboratory markersMonitoring toolsTransthyretin amyloid cardiomyopathy

Identifiers

PMID33915002
PMCPMC8239846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.