ArticleSchizophrenia bulletin2021
Reliability and Replicability of Implicit and Explicit Reinforcement Learning Paradigms in People With Psychotic Disorders.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Effort and substance use: differentiating tobacco use through reinforcement learning of effort based decision making.Journal of computational neuroscience · 2026Article
- 16p11.2 duplication and NMDA receptor antagonism have distinct impacts on reward learning and decision making.Psychopharmacology · 2026Article
- 16p11.2 duplication shows early male-biased impacts on reward learning, but NMDA receptor antagonism reduces optimal choice selection in both wildtypes and 16p11.2 duplication.bioRxiv : the preprint server for biology · 2025Article
- A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology.Schizophrenia bulletin · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- Modeling Decision-Making in Schizophrenia: Associations Between Computationally Derived Risk Propensity and Self-Reported Risk Perception.Schizophrenia bulletin · 2024Article
- Consistency within change: Evaluating the psychometric properties of a widely used predictive-inference task.Behavior research methods · 2024Article
- Test-retest reliability of reinforcement learning parameters.Behavior research methods · 2024Article
- Reinforcement learning profiles and negative symptoms across chronic and clinical high-risk phases of psychotic illness.European archives of psychiatry and clinical neuroscience · 2023Article
- Transdiagnostic Predictors of Everyday Functioning: Examining the Relationships of Depression and Reinforcement Learning.Schizophrenia bulletin · 2023Article
- Reliability of gamified reinforcement learning in densely sampled longitudinal assessments.PLOS digital health · 2023Article
- Interpersonal coordination in schizophrenia: a concise update on paradigms, computations, and neuroimaging findings.Psychoradiology · 2023Review
- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious Mental Illness (CNTRaCS) Consortium: Progress and Future Directions.Current topics in behavioral neurosciences · 2023Article
- Aberrant reward processing to positive versus negative outcomes across psychotic disorders.Journal of psychiatric research · 2022Article
- Article
- Belief Updating and Paranoia in Individuals With Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- A review of risky decision-making in psychosis-spectrum disorders.Clinical psychology review · 2022Review
- Confirmation Bias in the Course of Instructed Reinforcement Learning in Schizophrenia-Spectrum Disorders.Brain sciences · 2022Article
- Test-retest reliability of computational parameters versus manifest behavior for decisional flexibility in psychosis.Psychological assessmentArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMotivational deficits in people with psychosis may be a result of impairments in reinforcement learning (RL). Therefore, behavioral paradigms that can accurately measure these impairments and their change over time are essential.
methodsWe examined the reliability and replicability of 2 RL paradigms (1 implicit and 1 explicit, each with positive and negative reinforcement components) given at 2 time points to healthy controls (n = 75), and people with bipolar disorder (n = 62), schizoaffective disorder (n = 60), and schizophrenia (n = 68).
resultsInternal consistency was acceptable (mean α = 0.78 ± 0.15), but test-retest reliability was fair to low (mean intraclass correlation = 0.33 ± 0.25) for both implicit and explicit RL. There were no clear effects of practice for these tasks. Largely, performance on these tasks shows intact implicit and impaired explicit RL in psychosis. Symptom presentation did not relate to performance in any robust way.
conclusionsOur findings replicate previous literature showing spared implicit RL and impaired explicit reinforcement in psychosis. This suggests typical basal ganglia dopamine release, but atypical recruitment of the orbitofrontal and dorsolateral prefrontal cortices. However, we found that these tasks have only fair to low test-retest reliability and thus may not be useful for assessing change over time in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.