ArticlePloS one2021
Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Diverse toxin repertoire but limited metabolic capacities inferred from the draft genome assemblies of threeMicrobial genomics · 2025Article
- Jellyfish blooms through the microbial lens: temporal changes, cross-species and Jellyfish-water comparisons.Environmental microbiome · 2025Article
- Gut microbial community structure of the adult citrus root weevilFrontiers in insect science · 2025Article
- The endosymbiontmBio · 2024Article
- Microorganism Contribution to Mass-Reared Edible Insects: Opportunities and Challenges.Insects · 2024Review
- Dual proteomics of infected macrophages reveal bacterial and host players involved in the Francisella intracellular life cycle and cell to cell dissemination by merocytophagy.Scientific reports · 2024Article
- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and FemaleOxidative medicine and cellular longevity · 2023Article
- Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Development of Resistance to Clarithromycin and Amoxicillin-Clavulanic Acid inMicrobiology spectrum · 2022Article
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- The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship betweenmicroLife · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects are frequently infected with heritable bacterial endosymbionts. Endosymbionts have a dramatic impact on their host physiology and evolution. Their tissue distribution is variable with some species being housed intracellularly, some extracellularly and some having a mixed lifestyle. The impact of extracellular endosymbionts on the biofluids they colonize (e.g. insect hemolymph) is however difficult to appreciate because biofluid composition can depend on the contribution of numerous tissues. Here we investigate Drosophila hemolymph proteome changes in response to the infection with the endosymbiont Spiroplasma poulsonii. S. poulsonii inhabits the fly hemolymph and gets vertically transmitted over generations by hijacking the oogenesis in females. Using dual proteomics on infected hemolymph, we uncovered a weak, chronic activation of the Toll immune pathway by S. poulsonii that was previously undetected by transcriptomics-based approaches. Using Drosophila genetics, we also identified candidate proteins putatively involved in controlling S. poulsonii growth. Last, we also provide a deep proteome of S. poulsonii, which, in combination with previously published transcriptomics data, improves our understanding of the post-transcriptional regulations operating in this bacterium.
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