ArticlePLoS genetics2021
The genomics of rapid climatic adaptation and parallel evolution in North American house mice.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Regionally specific and highly pleiotropic loci together mediate skeletal evolution in tropical and temperate house mice.Genetics · 2026Article
- Historical and contemporary genomes of an endangered rodent reveal shifts in environmentally associated genes.Science advances · 2026Article
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- Alternative splicing contributes to plasticity and regulatory divergence in locally adapted house mice from the Americas.Molecular biology and evolution · 2026Article
- Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils.eLife · 2025Article
- Article
- Phenotypic and developmental dissection of an instance of the island rule.Evolution; international journal of organic evolution · 2025Article
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
- Phenotypic and Developmental Dissection of an Instance of the Island Rule.bioRxiv : the preprint server for biology · 2025Article
- Article
- Competing adaptations maintain nonadaptive variation in a wild cricket population.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas.PLoS genetics · 2024Article
- Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.PLoS genetics · 2024Article
- Tissue-specific and cis-regulatory changes underlie parallel, adaptive gene expression evolution in house mice.PLoS genetics · 2024Article
- Across two continents: the genomic basis of environmental adaptation in house mice (bioRxiv : the preprint server for biology · 2023Article
- Fatty acid metabolism decreased while sexual selection increased in brown rats spreading south.iScience · 2023Article
- Environmentally robustProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.bioRxiv : the preprint server for biology · 2023Article
- Detecting parallel polygenic adaptation to novel evolutionary pressure in wild populations: a case study in Atlantic cod (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Parallel changes in genotype and phenotype in response to similar selection pressures in different populations provide compelling evidence of adaptation. House mice (Mus musculus domesticus) have recently colonized North America and are found in a wide range of environments. Here we measure phenotypic and genotypic differentiation among house mice from five populations sampled across 21° of latitude in western North America, and we compare our results to a parallel latitudinal cline in eastern North America. First, we show that mice are genetically differentiated between transects, indicating that they have independently colonized similar environments in eastern and western North America. Next, we find genetically-based differences in body weight and nest building behavior between mice from the ends of the western transect which mirror differences seen in the eastern transect, demonstrating parallel phenotypic change. We then conduct genome-wide scans for selection and a genome-wide association study to identify targets of selection and candidate genes for body weight. We find some genomic signatures that are unique to each transect, indicating population-specific responses to selection. However, there is significant overlap between genes under selection in eastern and western house mouse transects, providing evidence of parallel genetic evolution in response to similar selection pressures across North America.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.