Observational studyPLoS neglected tropical diseases2021
Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon.
Observational study in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Clinical, parasitological, and hematologic profile of pregnant women with malaria in Colombia: a retrospective cross-sectional study.IJID regions · 2026Article
- Updating the frequency of CCR5Δ32 in Brazil: Descriptive analysis of malaria cases and controls from Acre State, Amazon region.Genetics and molecular biology · 2026Article
- VAR2CSA-reactive IgG in Brazilian women exposed toInfection and immunity · 2025Article
- Prevalence of submicroscopic congenital malaria and associated risk factors in an area of low endemicity of Guatemala.Malaria journal · 2025Article
- Parasite genotypes and host immune mediators in primary and recurrent episodes of vivax Malaria in Colombia.Revista peruana de medicina experimental y salud publica · 2025Article
- Facilitators and barriers of malaria prevention and treatment services to pregnant women in Ethiopia: a multi-level health system analysis, 2025.Malaria journal · 2025Article
- Current update on malaria in pregnancy: a systematic review.Tropical diseases, travel medicine and vaccines · 2025Review
- Challenges in managing gestational malaria due to Plasmodium vivax with severe complications: A clinical case from Colombia.IJID regions · 2025Article
- A Rare Presentation ofCase reports in medicine · 2025Article
- Association between peripheral markers in women with malaria in pregnancy and small newborns: A cross-sectional study.PLOS global public health · 2025Article
- Adverse pregnancy outcomes in maternal malarial infection: A systematic review and meta-analysis.New microbes and new infections · 2024Review
- Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.PLoS neglected tropical diseases · 2024Observational
- Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.Malaria journal · 2024Review
- A Pan Plasmodium lateral flow recombinase polymerase amplification assay for monitoring malaria parasites in vectors and human populations.Scientific reports · 2024Article
- Heterogeneity in the prevalence of subclinical malaria, other co-infections and anemia among pregnant women in rural areas of Myanmar: a community-based longitudinal study.Tropical medicine and health · 2024Article
- Review
- Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy.Genes · 2023Article
- Intermittent preventive treatment with Sulfadoxine pyrimethamine for malaria: a global overview and challenges affecting optimal drug uptake in pregnant women.Pathogens and global health · 2023Review
- Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice.Viruses · 2023Article
- Genetic diversity ofLancet regional health. Americas · 2023Article
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundMalaria in Brazil represents one of the highest percentages of Latin America cases, where approximately 84% of infections are attributed to Plasmodium (P.) vivax. Despite the high incidence, many aspects of gestational malaria resulting from P. vivax infections remain poorly studied. As such, we aimed to evaluate the consequences of P. vivax infections during gestation on the health of mothers and their neonates in an endemic area of the Amazon. METHODS AND
findingsWe have conducted an observational cohort study in Brazilian Amazon between January 2013 and April 2015. 600 pregnant women were enrolled and followed until delivery. After applying exclusion criteria, 329 mother-child pairs were included in the analysis. Clinical data regarding maternal infection, newborn's anthropometric measures, placental histopathological characteristics, and angiogenic and inflammatory factors were evaluated. The presence of plasma IgG against the P. vivax (Pv) MSP119 protein was used as marker of exposure and possible associations with pregnancy outcomes were analyzed. Multivariate logistic regression analysis revealed that P. vivax infections during the first trimester of pregnancy are associated with adverse gestational outcomes such as premature birth (adjusted odds ratio [aOR] 8.12, 95% confidence interval [95%CI] 2.69-24.54, p < 0.0001) and reduced head circumference (aOR 3.58, 95%CI 1.29-9.97, p = 0.01). Histopathology analysis showed marked differences between placentas from P. vivax-infected and non-infected pregnant women, especially regarding placental monocytes infiltrate. Placental levels of vasomodulatory factors such as angiopoietin-2 (ANG-2) and complement proteins such as C5a were also altered at delivery. Plasma levels of anti-PvMSP119 IgG in infected pregnant women were shown to be a reliable exposure marker; yet, with no association with improved pregnancy outcomes.
conclusionsThis study indicates that P. vivax malaria during the first trimester of pregnancy represents a higher likelihood of subsequent poor pregnancy outcomes associated with marked placental histologic modification and angiogenic/inflammatory imbalance. Additionally, our findings support the idea that antibodies against PvMSP119 are not protective against poor pregnancy outcomes induced by P. vivax infections.
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