Evidence map›Paper›PMID 33914591›Full record

ReviewAnnual review of neuroscience2021

How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.

Cristopher M Niell, Massimo Scanziani

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Visual computation in the cephalopod brain.Current opinion in neurobiology · 2026
    Review
  2. Calcium-binding protein expression cannot serve as a general classifier for GABAergic neurons in macaque cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Early Development of Direction Selectivity in the Higher Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  16. Article
  17. Article
  18. Synergistic Geniculate and Cortical Dynamics Facilitate a Decorrelated Spatial Frequency Code in the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cristopher M NiellDepartment of Biology and Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA; email: cniell@uoregon.edu.
Massimo ScanzianiDepartment of Physiology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, USA; email: massimo@ucsf.edu.

Funding

Validating Theoretical Models with Neurophysiology and OptogeneticsU19NS107613 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADESNIK, HILLEL · 2018 to 2022
$16.7M
MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORSR01NS123912 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN, XIN, SCANZIANI, MASSIMO · 2021 to 2025
$3.6M
Brain States and Flexible BehaviorRF1NS118461 · NINDS · UNIVERSITY OF OREGON · PI JARAMILLO, SANTIAGO, MCCORMICK, DAVID · 2020 to 2020
$2.4M
Neural Circuits for the Cortical Control of the Optokinetic ReflexR01EY025668 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCANZIANI, MASSIMO · 2016 to 2020
$2.0M
Brain States and Flexible BehaviorR01NS118461 · NINDS · UNIVERSITY OF OREGON · PI MCCORMICK, DAVID, NIELL, CRISTOPHER M · 2023 to 2024
$1.4M
Visual coding in freely moving behaviorR34NS111669 · NINDS · UNIVERSITY OF OREGON · PI NIELL, CRISTOPHER M · 2019 to 2019
$626k
NEI NIH HHS R01 EY025668NINDS NIH HHS R01 NS118461NINDS NIH HHS R01 NS123912NINDS NIH HHS R34 NS111669NINDS NIH HHS RF1 NS118461NINDS NIH HHS U19 NS107613
6 · The paper itself

Abstract

The mouse, as a model organism to study the brain, gives us unprecedented experimental access to the mammalian cerebral cortex. By determining the cortex's cellular composition, revealing the interaction between its different components, and systematically perturbing these components, we are obtaining mechanistic insight into some of the most basic properties of cortical function. In this review, we describe recent advances in our understanding of how circuits of cortical neurons implement computations, as revealed by the study of mouse primary visual cortex. Further, we discuss how studying the mouse has broadened our understanding of the range of computations performed by visual cortex. Finally, we address how future approaches will fulfill the promise of the mouse in elucidating fundamental operations of cortex.

Indexed as

Visual CortexAnimalsMiceNeuronsPhotic Stimulationbehavioral statecontextual modulationdirection selectivityorientation selectivityperceptionreceptive field

Identifiers

PMID33914591
PMCPMC9925090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.