Evidence map›Paper›PMID 33914261›Full record

ArticleCell biochemistry and biophysics2021

In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast Adenocarcinoma MCF-7 Cells.

Sema Caglar, Ahmet Altay, Mehmet Kuzucu, Bulent Caglar

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Ni(II) Complexes with Mixed Ligands, Reduced NInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sema CaglarDepartment of Chemistry, Faculty of Arts and Sciences, Erzincan Binali Yıldırım University, 24100, Erzincan, Turkey.
Ahmet AltayDepartment of Chemistry, Faculty of Arts and Sciences, Erzincan Binali Yıldırım University, 24100, Erzincan, Turkey. aaltay@erzincan.edu.tr.ORCID http://orcid.org/0000-0001-8120-8900
Mehmet KuzucuDepartment of Biology, Faculty of Arts and Sciences, Erzincan Binali Yıldırım University, 24100, Erzincan, Turkey.
Bulent CaglarDepartment of Chemistry, Faculty of Arts and Sciences, Erzincan Binali Yıldırım University, 24100, Erzincan, Turkey.
Erzincan Binali Yıldırım University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report the synthesis, characterization and anticancer activity of six novel complexes of non-steroidal anti-inflammatory drug niflumic acid with Co(II) and Ni(II). In vitro cytotoxicity screening in MCF-7, HepG2 and HT-29 cancer cell lines showed that the complex 3 [Co(nif)

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsApoptosisBreast NeoplasmsMembrane Potential, MitochondrialNickelNiflumic AcidAdenocarcinomaAnimalsCoordination ComplexesFemaleHT29 CellsHumansMCF-7 CellsMiceMitochondriaAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCoordination ComplexesNickelNiflumic AcidPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBreast cancerCytotoxicityFlow cytometryGene expressionNiflumic acid complexes

Identifiers

PMID33914261
OpenAlexW3157817163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.