Evidence map›Paper›PMID 33914185›Full record

ArticleEJNMMI physics2021

Population-based input function for TSPO quantification and kinetic modeling with [

Mercy I Akerele, Sara A Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A Gauthier, Ashish Raj, Claire Henchcliffe, P David Mozley, Nicolas A Karakatsanis, Ajay Gupta and 2 more

Abstract read
In one paragraph

Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. TSPO circadian pattern: a test-retest study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. DynamicRadiology. Imaging cancer · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mercy I AkereleDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA. mia4006@med.cornell.edu.ORCID http://orcid.org/0000-0001-8856-8183
Sara A ZeinDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Sneha PandyaDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Anastasia NikolopoulouDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Susan A GauthierDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Ashish RajDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Claire HenchcliffeDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
P David MozleyDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Nicolas A KarakatsanisDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Ajay GuptaDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
John BabichDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.
Sadek A NehmehDepartment of Radiology, Weill Cornell Medical College, New York, NY, 10021, USA.

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Identifying mechanisms of tissue injury in MS lesions: a multi-modality imaging approachR01NS104283 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUTHIER, SUSAN A · 2018 to 2022
$2.2M
NCATS NIH HHS RO1 NS104283NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1TR000457NINDS NIH HHS R01 NS104283
6 · The paper itself

Abstract

introductionQuantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to assess the reproducibility of [ MATERIALS AND

methodsEighteen subjects including six healthy volunteers (HV) and twelve Parkinson disease (PD) subjects from two [

resultsBland-Altman analysis showed systematic bias between test and retest studies. The corresponding mean bias and 95% limits of agreement (LOA) for the studied brain regions were 30% and ± 70%. Comparing PBIF- and PSAIF-based V

conclusionsPSAIF kinetic results are reproducible with PBIF, with variability in V

Indexed as

[11C]DPA-713Kinetic modelingNormalizationPopulation-based input function

Identifiers

PMID33914185
PMCPMC8085191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.