Evidence map›Paper›PMID 33914169›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2021

Mechanism of cyanocobalamin chlorination by hypochlorous acid.

Ilia A Dereven'kov, Vladimir S Osokin, Luciana Hannibal, Sergei V Makarov, Ilya A Khodov, Oskar I Koifman

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. The chlorite adduct of aquacobalamin: contrast with chlorite dismutase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  2. meso-Bromination of cyano- and aquacobalamins facilitates their processing into Co(II)-species by glutathione.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ilia A Dereven'kovIvanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation. derevenkov@gmail.com.ORCID 0000-0003-1332-4998
Vladimir S OsokinIvanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.
Luciana HannibalLaboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Center-University of Freiburg, 79106, Freiburg, Germany.ORCID 0000-0002-0911-5758
Sergei V MakarovIvanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.ORCID 0000-0003-1111-7186
Ilya A KhodovG.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Akademicheskaya Str. 1, 153045, Ivanovo, Russian Federation.ORCID 0000-0003-2439-9290
Oskar I KoifmanIvanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000, Ivanovo, Russian Federation.ORCID 0000-0003-2720-8111
Ivanovo State University of Chemistry and Technology · RUInstitute of Solution Chemistry · RUUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypochlorous acid (HOCl) is a strong oxidant produced by myeloperoxidase. Previous work suggested that HOCl modifies the corrin ring of cobalamins to yield chlorinated species via mechanisms that are incompletely understood. Herein, we report a mechanistic study on the reaction between cyanocobalamin (CNCbl, vitamin B

Indexed as

HalogenationHydrogen-Ion ConcentrationHypochlorous AcidMolecular StructureVitamin B 12Hypochlorous AcidVitamin B 121H–13C HSQCCobalaminsHypochlorous acidKineticsNMR

Identifiers

PMID33914169
OpenAlexW3159280381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.