Evidence map›Paper›PMID 33914085›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Incident Dementia, Glycated Hemoglobin (HbA1c) Levels, and Potentially Preventable Hospitalizations in People Aged 65 and Older With Diabetes.

Oleg Zaslavsky, Onchee Yu, Rod L Walker, Paul K Crane, Shelly L Gray, Tatiana Sadak, Soo Borson, Eric B Larson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Oleg ZaslavskyDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, USA.
Onchee YuKaiser Permanente Washington Health Research Institute, Seattle, USA.
Rod L WalkerKaiser Permanente Washington Health Research Institute, Seattle, USA.ORCID 0000-0002-8464-9805
Paul K CraneSchool of Medicine, University of Washington, Seattle, USA.
Shelly L GraySchool of Pharmacy, University of Washington, Seattle, USA.
Tatiana SadakDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, USA.
Soo BorsonPsychiatry and Behavioral Sciences Department, University of Washington, Seattle, USA.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, USA.
University of Washington · USKaiser Permanente Washington Health Research Institute · US

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Paul K Crane, Andrea Z. LaCroix · 2021 to 2026
$80.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Glucose Levels and Preventable Hospitalizations in Alzheimer and DiabetesR03AG061305 · NIA · UNIVERSITY OF WASHINGTON · PI ZASLAVSKY, OLEG · 2019 to 2020
$172k
NIA NIH HHS R03 AG061305NIA NIH HHS R03AG061305NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567
6 · The paper itself

Abstract

backgroundThis study was aimed to determine whether incident dementia and HbA1c levels are associated with increased rates of potentially preventable hospitalizations (PPHs) in persons with diabetes.

methodA total of 565 adults aged 65+ ever treated for diabetes were enrolled from Adult Changes in Thought study. PPHs were from principal discharge diagnoses and included diabetes PPH (dPPH), respiratory PPH (rPPH), urinovolemic PPH (uPPH), cardiovascular PPH, and other PPH. Poisson generalized estimating equations estimated rate ratios (RRs) and 95% confidence intervals (CIs) for the associations between dementia or HbA1c measures and rate of PPHs.

resultsA total of 562 individuals contributed 3 602 dementia-free years, and 132 individuals contributed 511 dementia follow-up years. One hundred twenty-eight (23%) dementia-free individuals had 210 PPH admissions and a crude rate of 58 per 1 000 person-years, while 55 (42%) individuals with dementia had 93 PPH admissions and a crude rate of 182 per 1 000 person-years. The adjusted RR (95% CI) comparing rates between dementia and dementia-free groups were 2.27 (1.60, 3.21) for overall PPH; 5.90 (2.70, 12.88) for dPPH; 5.17 (2.49, 10.73) for uPPH; and 2.01 (1.06, 3.83) for rPPH. Compared with HbA1c of 7%-8% and adjusted for dementia, the RR (95% CI) for overall PPH was 1.43 (1.00, 2.06) for >8% HbA1c and 1.18 (0.85, 1.65) for <7% HbA1c. The uPPH RR was also increased, comparing >8% and <7% HbA1c levels.

conclusionIncident dementia is associated with higher rates of PPHs among people with diabetes, especially PPHs due to diabetes, urinary tract infection (UTI), and dehydration. Potential evidence suggested that HbA1c levels of >8% versus lower levels are associated with higher rates of overall PPHs and UTI- and dehydration-related PPHs.

Indexed as

DementiaDiabetes MellitusDehydrationGlycated HemoglobinHospitalizationHumansGlycated HemoglobinAvoidable admissionsDehydrationGlucoseHyperglycemiaUTI

Identifiers

PMID33914085
PMCPMC8514059
OpenAlexW3159036061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.