Evidence map›Paper›PMID 33913810›Full record

ArticleeLife2021

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex.

Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 64 citations in OpenAlex.

  1. The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras-MAPK Signaling in Epithelioid Hemangioendothelioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
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  9. Targeting the Hippo pathway in cancer.Nature reviews. Drug discovery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Nicole Merritt *Department of Pathology, University of Iowa, Iowa City, United States.
Keith Garcia *Department of Pathology, University of Iowa, Iowa City, United States.ORCID 0000-0002-6078-5159
Dushyandi RajendranLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States.
Zhen-Yuan LinLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States.
Xiaomeng ZhangPeter MacCallum Cancer Centre, Melbourne, Australia.
Katrina A MitchellPeter MacCallum Cancer Centre, Melbourne, Australia.
Nicholas BorcherdingDepartment of Pathology and Immunology, Washington University, St. Louis, United States.
Colleen FullenkampDepartment of Pathology, University of Iowa, Iowa City, United States.
Michael S ChimentiIowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa City, United States.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States.ORCID 0000-0002-6090-4437
Kieran F HarveyPeter MacCallum Cancer Centre, Melbourne, Australia.
Munir R TanasDepartment of Pathology, University of Iowa, Iowa City, United States.ORCID 0000-0002-6779-2642
University of Iowa · USMount Sinai Hospital · USThe University of Melbourne · AUPeter MacCallum Cancer Centre · AUWashington University in St. Louis · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Epigenetic modulation of the TAZ-CAMTA1 transcriptional program by the Ada2a-containing histone acetyltransferase complexR01CA237031 · NCI · UNIVERSITY OF IOWA · PI TANAS, MUNIR · 2020 to 2024
$1.9M
Upstream regulation of TAZ and YAP in sarcomas: Towards combinatorial therapytargeting the Hippo pathwayI01BX003644 · VA · IOWA CITY VA MEDICAL CENTER · PI TANAS, MUNIR · 2017 to 2025
–
BLRD VA I01 BX003644CIHR FDN 144301NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA237031
6 · The paper itself

Abstract

Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogenic drivers of EHE. A combined proteomic/genetic screen in human cell lines identified YEATS2 and ZZZ3, components of the

Indexed as

AnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCalcium-Binding ProteinsCell Cycle ProteinsHemangioendothelioma, EpithelioidHistone AcetyltransferasesHumansIntracellular Signaling Peptides and ProteinsMiceProtein BindingTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTranscriptomeBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCalcium-Binding ProteinsCAMTA1 protein, humanCell Cycle ProteinsHistone AcetyltransferasesIntracellular Signaling Peptides and ProteinsTFE3 protein, humanTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanYY1AP1 protein, humanATAC complexcancer biologychimeric transcription factorschromosomesepigeneticsfusion proteinsgene expressionhippo pathwayhumanmousesarcomas

Identifiers

PMID33913810
PMCPMC8143797
OpenAlexW3157581414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.