ArticleeLife2021
The causal role of auditory cortex in auditory working memory.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Task-dependent neural dynamics in hippocampal CA1 during auditory and visual perceptual decision-making in rats.Brain structure & function · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Differences of Gradient Connectivity and Ventricle Volumes in Long-Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures.Human brain mapping · 2026Article
- Motor working memory.Trends in cognitive sciences · 2026Review
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
- The what, which, when, why and who of Off responses in the auditory system.The Journal of physiology · 2025Review
- Article
- Differential Effects of Visual and Auditory Cognitive Tasks on Smooth Pursuit Eye Movements.Psychophysiology · 2025Article
- Auditory cortical neurons are recruited to encode fear signals and anxiety by neuroligin-3-mediated synapse formation.Translational psychiatry · 2025Article
- A spatial code for temporal information is necessary for efficient sensory learning.Science advances · 2025Article
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dynamics and maintenance of categorical responses in primary auditory cortex during task engagement.eLife · 2023Article
- Bias in Prestimulus Motor Cortical Activity Determines Decision-making Error in Rodents.Experimental neurobiology · 2023Article
- CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.Cellular and molecular neurobiology · 2023Article
- Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy.Neuroimage. Reports · 2023Article
- Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss.CNS neuroscience & therapeutics · 2023Article
- 3T vs. 7T fMRI: capturing early human memory consolidation after motor task utilizing the observed higher functional specificity of 7T.Frontiers in neuroscience · 2023Article
- The neural coding of tonal working memory load: An functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Working memory (WM), the ability to actively hold information in memory over a delay period of seconds, is a fundamental constituent of cognition. Delay-period activity in sensory cortices has been observed in WM tasks, but whether and when the activity plays a functional role for memory maintenance remains unclear. Here, we investigated the causal role of auditory cortex (AC) for memory maintenance in mice performing an auditory WM task. Electrophysiological recordings revealed that AC neurons were active not only during the presentation of the auditory stimulus but also early in the delay period. Furthermore, optogenetic suppression of neural activity in AC during the stimulus epoch and early delay period impaired WM performance, whereas suppression later in the delay period did not. Thus, AC is essential for information encoding and maintenance in auditory WM task, especially during the early delay period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.