Evidence map›Paper›PMID 33913701›Full record

ArticleACS chemical biology2021

Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by

Oleksandr Yushchuk, Natalia M Vior, Andres Andreo-Vidal, Francesca Berini, Christian Rückert, Tobias Busche, Elisa Binda, Jörn Kalinowski, Andrew W Truman, Flavia Marinelli

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Isolation and characterization of endophytic actinobacteria associated with Artemisia judaica L. ssp. sahariensis from desert regions in Algeria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Modern Trends in Natural Antibiotic Discovery.Life (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Frontiers in microbiology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Oleksandr YushchukDepartment of Biotechnology and Life Sciences, University of Insubria, via J. H. Dunant 3, 21100 Varese, Italy.ORCID 0000-0003-3296-8297
Natalia M ViorDepartment of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, United Kingdom.
Andres Andreo-VidalDepartment of Biotechnology and Life Sciences, University of Insubria, via J. H. Dunant 3, 21100 Varese, Italy.
Francesca BeriniDepartment of Biotechnology and Life Sciences, University of Insubria, via J. H. Dunant 3, 21100 Varese, Italy.
Christian RückertTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
Tobias BuscheTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
Elisa BindaDepartment of Biotechnology and Life Sciences, University of Insubria, via J. H. Dunant 3, 21100 Varese, Italy.
Jörn KalinowskiTechnology Platform Genomics, CeBiTec, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
Andrew W TrumanDepartment of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0001-5453-7485
Flavia MarinelliDepartment of Biotechnology and Life Sciences, University of Insubria, via J. H. Dunant 3, 21100 Varese, Italy.ORCID 0000-0001-9195-6777
University of Insubria · ITBielefeld University · DEJohn Innes Centre · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790
6 · The paper itself

Abstract

Glycopeptide antibiotics (GPAs) are last defense line drugs against multidrug-resistant Gram-positive pathogens. Natural GPAs teicoplanin and vancomycin, as well as semisynthetic oritavancin, telavancin, and dalbavancin, are currently approved for clinical use. Although these antibiotics remain efficient, emergence of novel GPA-resistant pathogens is a question of time. Therefore, it is important to investigate the natural variety of GPAs coming from so-called "rare" actinobacteria. Herein we describe a novel GPA producer-

Indexed as

ActinobacteriaAnti-Bacterial AgentsBacterial ProteinsBase SequenceComputer SimulationDrug Evaluation, PreclinicalGene Expression Regulation, BacterialGenomicsGlucosamineGlycopeptidesMultigene FamilyRecombinant ProteinsTandem Mass SpectrometryTeicoplaninA 40926Anti-Bacterial AgentsBacterial ProteinsdalbavancinGlucosamineGlycopeptidesRecombinant ProteinsTeicoplanin

Identifiers

PMID33913701
PMCPMC8291499
OpenAlexW3159250775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.