Evidence map›Paper›PMID 33913558›Full record

ArticleJournal of medical virology2021

Evaluation of the diagnostic performance of nine commercial RT-PCR kits for the detection of SARS-CoV-2 in Colombia.

Carolina Hernández, Carolina Florez, Sergio Castañeda, Nathalia Ballesteros, David Martínez, Adriana Castillo, Marina Muñoz, Sergio Gomez, Angelica Rico, Liseth Pardo and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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  5. COVID-19 diagnostics: Molecular biology to nanomaterials.Clinica chimica acta; international journal of clinical chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Carolina HernándezCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Carolina FlorezInstituto Nacional de Salud, Bogotá, Colombia.
Sergio CastañedaCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Nathalia BallesterosCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
David MartínezCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Adriana CastilloCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Marina MuñozCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.
Sergio GomezInstituto Nacional de Salud, Bogotá, Colombia.
Angelica RicoInstituto Nacional de Salud, Bogotá, Colombia.
Liseth PardoInstituto Nacional de Salud, Bogotá, Colombia.
Alberto Paniz-MondolfiIcahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0003-1259-1736
Juan David RamírezCentro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.ORCID 0000-0002-1344-9312
Universidad del Rosario · COInstituto Nacional de Salud · COIncubadora Venezolana de la Ciencia · VE

Funding

Universidad del Rosario Internal funds
6 · The paper itself

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has led to the design and development of multiple reverse-transcription polymerase chain reaction kits aimed to facilitate the rapid scale-up of molecular testing for massive screening. We evaluated the diagnostic performance of nine commercial kits, which showed optimal performance and high discriminatory power. However, we observed differences in terms of sensitivity, specificity, and E gene Ct Values and discuss these results in light of the influence of SARS-CoV-2 genetic variability and its potential impact in current molecular diagnostic assays.

Indexed as

ColombiaCOVID-19COVID-19 TestingHumansMolecular Diagnostic TechniquesReagent Kits, DiagnosticReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Sensitivity and SpecificityReagent Kits, Diagnosticcommercial kitsmolecular diagnosisperformanceRT-PCRSARS-CoV-2

Identifiers

PMID33913558
PMCPMC8242747
OpenAlexW3157785229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.