ArticleNeurosurgery2021
Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinically Feasible White Matter Fiber Tractography in Peritumoral Zones With Cerebral Vasogenic Edema.Magnetic resonance in medicine · 2026Article
- Biophysical Diffusion MRI Models Better Identify White Matter Tracts in Edema.Tomography (Ann Arbor, Mich.) · 2026Article
- Improving tractography in peri-lesional oedema using constrained spherical deconvolution in paediatric neurosurgery patients.Brain structure & function · 2026Article
- Passive intraoperative motor fMRI under general anesthesia during open-craniotomy glioma surgery: a prospective technical feasibility study.Brain & spine · 2026Article
- The Role of Deep Cerebral Tracts in Predicting Postoperative Aphasia: An nTMS-Based Investigation of the Corticothalamic Fibers.Human brain mapping · 2025Article
- Article
- The Brain Connectome for Clinical Neuroscience.Advances in experimental medicine and biology · 2024Review
- Free-water correction DTI-based tractography in brain tumor surgery: assessment with functional and electrophysiological mapping of the white matter.Acta neurochirurgica · 2023Article
- Preoperative validation of edema-corrected tractography in neurosurgical practice: translating surgeon insights into novel software implementation.Frontiers in neurology · 2023Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundA limitation of diffusion tensor imaging (DTI)-based tractography is peritumoral edema that confounds traditional diffusion-based magnetic resonance metrics.
objectiveTo augment fiber-tracking through peritumoral regions by performing novel edema correction on clinically feasible DTI acquisitions and assess the accuracy of the fiber-tracks using intraoperative stimulation mapping (ISM), task-based functional magnetic resonance imaging (fMRI) activation maps, and postoperative follow-up as reference standards.
methodsEdema correction, using our bi-compartment free water modeling algorithm (FERNET), was performed on clinically acquired DTI data from a cohort of 10 patients presenting with suspected high-grade glioma and peritumoral edema in proximity to and/or infiltrating language or motor pathways. Deterministic fiber-tracking was then performed on the corrected and uncorrected DTI to identify tracts pertaining to the eloquent region involved (language or motor). Tracking results were compared visually and quantitatively using mean fiber count, voxel count, and mean fiber length. The tracts through the edematous region were verified based on overlay with the corresponding motor or language task-based fMRI activation maps and intraoperative ISM points, as well as at time points after surgery when peritumoral edema had subsided.
resultsVolume and number of fibers increased with application of edema correction; concordantly, mean fractional anisotropy decreased. Overlay with functional activation maps and ISM-verified eloquence of the increased fibers. Comparison with postsurgical follow-up scans with lower edema further confirmed the accuracy of the tracts.
conclusionThis method of edema correction can be applied to standard clinical DTI to improve visualization of motor and language tracts in patients with glioma-associated peritumoral edema.
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