ArticleNeurosurgery2021
A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Deep Brain Stimulation for Depression Informed by Intracranial Recordings.Biological psychiatry · 2022Trial
- Toward Individualized Deep Brain Stimulation: A Stereoelectroencephalography-Based Workflow for Neurostimulation Target Identification.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- Deep brain stimulation clinical trials: a framework to accelerate recruitment, retention, and technology translation.Frontiers in human neuroscience · 2026Article
- Contemporary Ethical Considerations in Psychiatric Neurosurgery.Stereotactic and functional neurosurgery · 2026Review
- A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Nanomedicine in Neuroprotection, Neuroregeneration, and Blood-Brain Barrier Modulation: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Beta activity in human anterior cingulate cortex mediates reward biases.Nature communications · 2024Article
- Opportunities and challenges for the use of deep brain stimulation in the treatment of refractory major depression.Discover mental health · 2024Review
- Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements.Frontiers in human neuroscience · 2024Article
- Graph Theory and Modeling of Network Topology in Clinical Neurosurgery.Advances in experimental medicine and biology · 2024Review
- Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Decoding Depression Severity From Intracranial Neural Activity.Biological psychiatry · 2023Article
- Machine learning classifiers for electrode selection in the design of closed-loop neuromodulation devices for episodic memory improvement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Prefrontal network engagement by deep brain stimulation in limbic hubs.Frontiers in human neuroscience · 2023Article
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- Neuromodulation for treatment-resistant depression: Functional network targets contributing to antidepressive outcomes.Frontiers in human neuroscience · 2023Review
- Automated optimization of deep brain stimulation parameters for modulating neuroimaging-based targets.Journal of neural engineering · 2022Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Deep brain stimulation (DBS) has emerged as a promising therapy for neuropsychiatric illnesses, including depression and obsessive-compulsive disorder, but has shown inconsistent results in prior clinical trials. We propose a shift away from the empirical paradigm for developing new DBS applications, traditionally based on testing brain targets with conventional stimulation paradigms. Instead, we propose a multimodal approach centered on an individualized intracranial investigation adapted from the epilepsy monitoring experience, which integrates comprehensive behavioral assessment, such as the Research Domain Criteria proposed by the National Institutes of Mental Health. In this paradigm-shifting approach, we combine readouts obtained from neurophysiology, behavioral assessments, and self-report during broad exploration of stimulation parameters and behavioral tasks to inform the selection of ideal DBS parameters. Such an approach not only provides a foundational understanding of dysfunctional circuits underlying symptom domains in neuropsychiatric conditions but also aims to identify generalizable principles that can ultimately enable individualization and optimization of therapy without intracranial monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.