Evidence map›Paper›PMID 33913240›Full record

ReviewEMBO reports2021

Get closer and make hotspots: liquid-liquid phase separation in plants.

Jiwoo Kim, Hongwoo Lee, Hong Gil Lee, Pil Joon Seo

Abstract readReview
In one paragraph

Review in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  10. Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025
    Review
  11. Review
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  15. Analysis of Phase Separation of EARLY FLOWERING 3.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  16. Heterologous Expression of TwoInternational journal of molecular sciences · 2023
    Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiwoo KimDepartment of Chemistry, Seoul National University, Seoul, Korea.
Hongwoo LeeDepartment of Chemistry, Seoul National University, Seoul, Korea.
Hong Gil LeePlant Genomics and Breeding Institute, Seoul National University, Seoul, Korea.
Pil Joon SeoDepartment of Chemistry, Seoul National University, Seoul, Korea.ORCID 0000-0002-5499-3138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless compartments in a cell and allows the spatiotemporal organization of biochemical reactions by concentrating macromolecules locally. In plants, LLPS defines cellular reaction hotspots, and stimulus-responsive LLPS is tightly linked to a variety of cellular and biological functions triggered by exposure to various internal and external stimuli, such as stress responses, hormone signaling, and temperature sensing. Here, we provide an overview of the current understanding of physicochemical forces and molecular factors that drive LLPS in plant cells. We illustrate how the biochemical features of cellular condensates contribute to their biological functions. Additionally, we highlight major challenges for the comprehensive understanding of biological LLPS, especially in view of the dynamic and robust organization of biochemical reactions underlying plastic responses to environmental fluctuations in plants.

Indexed as

Intrinsically Disordered ProteinsPlantsIntrinsically Disordered Proteinscondensateintrinsically disordered proteinliquid-liquid phase separationmultivalent interactionprion-like domain

Identifiers

PMID33913240
PMCPMC8097390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.