ReviewJournal of sleep research2021
ENIGMA-Sleep: Challenges, opportunities, and the road map.
Open access · bronzeAbstract readReview
In one paragraph
Review in Journal of sleep research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: A revisited neuroimaging meta-analysis of 39 studies.Sleep medicine reviews · 2023Pooled it
- Is there any consistent structural and functional brain abnormality in narcolepsy? A meta-analytic perspective.Neuroscience and biobehavioral reviews · 2022Pooled it
- A neural signature of sleep deprivation in the human brain.Nature communications · 2026Article
- Prediction of cognitive performance by demographics, sleep, and brain morphometry: machine learning findings from ENIGMA-Sleep Working Group.Research square · 2026Article
- Listening Effort, Sleep Quality, and Digital Addiction: Exploring Their Links.Brain and behavior · 2026Article
- Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function.iScience · 2026Article
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.Scientific reports · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Brain signature of sleep quality.Sleep · 2025Article
- The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy.Stem cell research & therapy · 2025Review
- Article
- Lower motor performance is linked with poor sleep quality, depressive symptoms, and grey matter volume alterations.bioRxiv : the preprint server for biology · 2024Article
- Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Discriminating Paradoxical and Psychophysiological Insomnia Based on Structural and Functional Brain Images: A Preliminary Machine Learning Study.Brain sciences · 2023Article
- Visual Attention and Poor Sleep Quality.Frontiers in neuroscience · 2022Article
- White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.Frontiers in human neuroscience · 2022Article
- Sleep in Individuals with ADHD: Prevalence, Impacts, Causes, and Treatments.Current topics in behavioral neurosciences · 2022Article
- A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients.Cancer metastasis reviews · 2021Review
- Alterations of Subcortical Brain Structures in Paradoxical and Psychophysiological Insomnia Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 20 institutions in 15 countries.
Masoud TahmasianInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.ORCID 0000-0003-3999-3807
André AlemanUniversity Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Ole A AndreassenNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Inst of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Zahra ArabInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.ORCID 0000-0001-6210-4532
Marion BailletGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Francesco BenedettiPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Tom BresserDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Joanna BrightImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID 0000-0002-0695-0491
Michael W L CheeCentre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Daphne ChylinskiGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Wei ChengInstitute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.
Michele DeantoniGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Martin DreslerDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Simon B EickhoffInstitute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
Claudia R EickhoffInstitute of Neuroscience and Medicine, Structural and functional organisation of the brain (INM-1), Research Centre Jülich, Jülich, Germany.
Torbjørn ElvsåshagenNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Jianfeng FengInstitute of Science and Technology for Brain-inspired intelligence, Fudan University, Shanghai, China.
Jessica C Foster-DingleyDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Habib GanjgahiDepartment of Statistics, University of Oxford, Oxford, UK.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Nynke A GroenewoldSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Tiffany C HoDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Seung Bong HongDepartment of Neurology, Samsung Medical Center, SBRI (Samsung Biomedical Research Institute), Sungkyunkwan University School of Medicine, Seoul, Korea.
Josselin HouenouUniv Paris Saclay, NeuroSpin neuroimaging platform, Psychiatry Team, UNIACT Lab, CEA Saclay, Gif-Sur-Yvette Cedex, France.ORCID 0000-0003-3166-5606
Benson IrunguDepartment of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Habibolah KhazaieSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Hosung KimLaboratory of Neuro Imaging at USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Ekaterina KoshmanovaGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Desi KocevskaDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Oti Lakbila-KamalDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Jeanne LeerssenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Meng LiClinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany.
Annemarie I LuikDepartment of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0001-7517-197X
Vincenzo MutoGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.ORCID 0000-0001-5100-9927
Justinas NarbutasGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Gustav NilsonneDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5273-0150
Victoria S O'CallaghanQueensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia.ORCID 0000-0002-0818-1323
Alexander OlsenDepartment of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID 0000-0001-8691-3860
Ricardo S OsorioHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-2735-9609
Sara PolettiPsychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Govinda PoudelMary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Vic., Australia.
Joyce E ReesenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Liesbeth RenemanDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Mathilde ReytGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Dieter RiemannDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID 0000-0002-1968-6220
Ivana RosenzweigSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.ORCID 0000-0003-2152-9694
Masoumeh RostampourSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Amin SaberiInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.ORCID 0000-0002-7043-0722
Julian SchielDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Christina SchmidtGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Anouk SchranteeDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Emma SciberrasDepartment of Paediatrics, University of Melbourne, Parkville, Vic., Australia.
Tim J SilkDepartment of Paediatrics, University of Melbourne, Parkville, Vic., Australia.
Kang SimInstitute of Mental Health, Buangkok, Singapore.
Hanne SmevikDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0002-7361-9387
Jair C SoaresDepartment of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Kai SpiegelhalderDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Puneet TalwarGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Sandra TammDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Giana L TeresiDepartment of Psychology, Stanford University, Stanford, CA, USA.
Sofie L ValkInstitute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.ORCID 0000-0003-2998-6849
Eus Van SomerenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.ORCID 0000-0002-9970-8791
Gilles VandewalleGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.ORCID 0000-0003-2483-2752
Maxime Van EgrooGIGA-Institute, Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab, University of Liège, Liège, Belgium.
Henry VölzkeInstitute for Community Medicine, Department SHIP/Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
Martin WalterClinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany.
Rick WassingDepartment of Sleep and Circadian Research, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.ORCID 0000-0003-2346-9891
Frederik D WeberDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Antoine WeihsDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-7113-0027
Lars Tjelta WestlyeNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Inst of Clinical Medicine, University of Oslo, Oslo, Norway.
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia.ORCID 0000-0001-7133-4970
Mon-Ju WuDepartment of Psychology and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Nathalia ZakNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Inst of Clinical Medicine, University of Oslo, Oslo, Norway.
Mojtaba ZareiInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
University of Liège · BENetherlands Institute for Neuroscience · NLOslo University Hospital · NOShahid Beheshti University · IRUniversitätsmedizin Greifswald · DEUniversity of Freiburg · DEUniversity of Southern California · USAmsterdam University Medical Centers · NLDeakin University · AUFudan University · CNHeinrich Heine University Düsseldorf · DEJena University Hospital · DEKermanshah University of Medical Sciences · IRNorwegian University of Science and Technology · NORadboud University Nijmegen · NLStockholm University · SEThe University of Queensland · AUThe University of Texas Health Science Center at Houston · USUniversity of Cape Town · ZAVita-Salute San Raffaele University · IT
Funding
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyR01AG056531 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEAN-LOUIS, GIRARDIN, OSORIO, RICARDO S · 2018 to 2022
$6.7MPromoting Academic Workforce Development in Behavioral Medicine and Sleep Disorders ResearchR25HL105444 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Girardin Jean-Louis, Tatjana Rundek · 2010 to 2026
$5.8MSleep Aging and Risk for Alzheimer's disease-Resubmission-1R01AG056031 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OSORIO, RICARDO S · 2018 to 2022
$4.4MThe Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881kBody Composition And Biomarkers Of Knee OsteoarthritisZ01AG000914 · NIA · AGING · PI LING, SHARI M. · 2002 to 2003
–FNRS-Belgium 3.4516.11FNRS-Belgium F.4513.17FNRS-Belgium T.0242.19Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project)Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU)Max-Planck-GesellschaftMC was supported by NMRC/ STaR/0015/2013 and NMRC/STaR May 19-001National Funds FNRS Scientific ResearchNHLBI NIH HHS R25 HL105444NIA NIH HHS R01 AG056031NIA NIH HHS R01 AG056531NIMH NIH HHS K01 MH117442Riksbankens Jubileumsfond P15-0310:1Université de LiègeWallonia-Brussels Federation ARC - 09/14-03WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant WELBIO-CR-2010-06E
Abstract
Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.
Indexed as
BrainHumansNeuroimagingSample SizeSleep DeprivationENIGMA consortiumlarge-scale collaborationneurogeneticsneuroimagingsleep
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.