ReviewDrugs & aging2021
Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression.
Review in Drugs & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation.BMC medicine · 2025Trial
- The association between ultra-processed food exposure and cognition in older adults.GeroScience · 2026Article
- Cellular heterogeneity and multicellular mechanisms in the pathogenesis of late-life depression: insights from single-cell and spatial multi-omics.Frontiers in immunology · 2026Review
- Identifying leading anti-inflammatory dietary determinants of depression and loneliness in older adults.Brain, behavior, & immunity - health · 2025Article
- Brain inflammaging in the pathogenesis of late-life depression.Human cell · 2024Review
- Developing prediction algorithms for late-life depression using wearable devices: a cohort study protocol.BMJ open · 2024Article
- Association between Dietary Antioxidant Capacity in Midlife and Depressive Symptoms in Late Life: The Singapore Chinese Health Study.Antioxidants (Basel, Switzerland) · 2024Article
- Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic.Frontiers in psychiatry · 2023Review
- Analysis of the prescribing pattern of antidepressants and the side effects in depression patients.Journal of family medicine and primary care · 2022Review
- Immune targets for therapeutic development in depression: towards precision medicine.Nature reviews. Drug discovery · 2022Review
- Effects of Modified Electroconvulsive Therapy on Serum Cortisol, Nesfatin-1, and Pro-inflammatory Cytokine Levels in Elderly Patients With Treatment-Resistant Depression.Frontiers in endocrinology · 2022Article
- Clinical symptoms and their relationship with cognitive impairment in elderly patients with depressive disorder.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a common and highly disabling condition in older adults. It is a heterogenous disorder and there is emerging evidence of a link between inflammation and depression in older patients, with a possible inflammatory subtype of depression. Persistent low-level inflammation, from several sources including psychological distress and chronic disease, can disrupt monoaminergic and glutaminergic systems to create dysfunctional brain networks. Despite the evidence for the role of inflammation in depression, there is insufficient evidence to recommend use of any putative anti-inflammatory agent in the treatment of depression in older adults at this stage. Further characterisation of markers of inflammation and stratification of participants with elevated rates of inflammatory markers in treatment trials is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.