Evidence map›Paper›PMID 33912986›Full record

ArticleAbdominal radiology (New York)2021

Cryoablation of renal tumors: long-term follow-up from a multicenter experience.

Fulvio Stacul, Camilla Sachs, Fabiola Giudici, Michele Bertolotto, Michele Rizzo, Nicola Pavan, Luca Balestreri, Oliviero Lenardon, Alessandro Pinzani, Lisa Pola and 3 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Management of Renal Cell Carcinoma: Promising Biomarkers and the Challenges to Reach the Clinic.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Canadian Urological Association guideline: Management of small renal masses - Full-text.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Fulvio StaculDepartment of Radiology, Ospedale Maggiore, Trieste, Italy.
Camilla SachsDepartment of Radiology, University of Trieste, Trieste, Italy.
Fabiola GiudiciUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Michele BertolottoDepartment of Radiology, University of Trieste, Trieste, Italy.
Michele RizzoDepartment of Urology, University of Trieste, Trieste, Italy.
Nicola PavanDepartment of Urology, University of Trieste, Trieste, Italy.
Luca BalestreriSOC Radiologia, Centro di Riferimento Oncologico Aviano, Aviano, Italy.
Oliviero LenardonSOC Urologia, Ospedale Santa Maria degli Angeli, Pordenone, Italy.
Alessandro PinzaniUO di Radiologia Dolo, AULSS 3, Serenissima, Italy.
Lisa PolaUO Urologia Dolo, AULSS 3, Serenissima, Italy.
Calogero CiceroDepartment of Radiology, San Bassano Hospital, Bassano del Grappa, Italy.
Antonio CeliaDepartment of Urology, San Bassiano Hospital, Bassano del Grappa, Italy.
Maria Assunta CovaDepartment of Radiology, University of Trieste, Trieste, Italy. m.cova@fmc.units.it.
University of Trieste · ITOspedale San Bassiano · ITAzienda Ospedaliera Santa Maria Degli Angeli · ITCentro di Riferimento Oncologico · ITOspedale Maggiore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo retrospectively investigate long-term outcomes of renal cryoablation from a multicenter database.

methods338 patients with 363 renal tumors underwent cryoablation in 4 centers in North-Eastern Italy. 340/363 tumors (93.7%) were percutaneously treated with CT guidance. 234 (68.8%) were treated after conscious sedation, 76 (22.3%) under local lidocaine anesthesia only and 30 (8.8%) under general anesthesia. Treatment efficacy and complication rate considered all procedures. Oncologic outcomes considered a subset of 159 patients with 159 biopsy proven renal cell carcinoma.

resultsMean tumor size was 2.53 cm. Technical success was achieved in 355/363 (97.8%) treatments. Treatment efficacy after the first treatment was achieved in 348/363 (95.9%) tumors. Statistical analysis revealed a significant lower treatment efficacy for ASA score >3, Padua score >8, tumor size >2.5 cm, use of >2 cryoprobes, presence of one single kidney. In the subset of 159 patients, recurrence-free survival rates were 90.5% (95% CI 83.0%, 94.9%) at 3 years and 82.4% (95% CI 72.0%, 89.4%) at 5 years; overall survival rates were 96.0% (95% CI 90.6%, 98.3%) at 3 years and 91.0% (95% CI 81.7%, 95.7%) at 5 years; no patient in this subset developed metastatic disease. Clavien-Dindo >1 complications were recorded in 14/369 procedures (3.8%) and were related to age >70 years, tumor size >4 cm and use of >2 cryoprobes.

conclusionCryoablation performed across four different centers in a large cohort of predominantly small renal tumors showed that this technique provides good recurrence-free survival rates and overall survival rates at three- and five-year with very low major complications rate.

Indexed as

Carcinoma, Renal CellCryosurgeryKidney NeoplasmsAgedFollow-Up StudiesHumansRetrospective StudiesTreatment OutcomeAblation techniquesCryoablationKidney neoplasmMulticenter study

Identifiers

PMID33912986
PMCPMC8346457
OpenAlexW3157271280

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.