Evidence map›Paper›PMID 33912852›Full record

ArticleHGG advances2021

Cutaneous and hepatic vascular lesions due to a recurrent somatic

Nelson Ugwu, Lihi Atzmony, Katharine T Ellis, Gauri Panse, Dhanpat Jain, Christine J Ko, Naiem Nassiri, Keith A Choate

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in HGG advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Lymphatic System Development and Function.Current cardiology reports · 2024
    Review
  5. SomaticStroke and vascular neurology · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nelson UgwuDepartment of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Lihi AtzmonyDepartment of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Katharine T EllisDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Gauri PanseDepartment of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Dhanpat JainDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Christine J KoDepartment of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Naiem NassiriDivision of Vascular and Endovascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA.
Keith A ChoateDepartment of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.
Yale University · USMarymount University · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Yale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8M
Training in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026
$7.8M
Genetics and Pathobiology of Cutaneous Mosaic DisordersR01AR071491 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE · 2018 to 2026
$4.2M
NCATS NIH HHS UL1 TR001863NHGRI NIH HHS UM1 HG006504NIAMS NIH HHS R01 AR071491NIAMS NIH HHS T32 AR007016NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

The term "cavernous hemangioma" has been used to describe vascular anomalies with histology featuring dilated vascular spaces, vessel walls consisting mainly of fibrous stromal bands lined by a layer of flattened endothelial cells, and an irregular outer rim of interrupted smooth muscle cells. Hepatic hemangiomas (HHs) and cutaneous venous malformations (VMs) share this histologic pattern, and we examined lesions in both tissues to identify genetic drivers. Paired whole-exome sequencing (WES) of lesional tissue and normal liver in HH subjects revealed a recurrent

Identifiers

PMID33912852
PMCPMC8078848
OpenAlexW3133805310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.