Evidence map›Paper›PMID 33912803›Full record

ArticleAME case reports2021

A case report of microsatellite instability (MSI)-high,

Nicholas C DeVito, Colm Kelleher, Kyle C Strickland, James Abbruzzese, Carey Anders, Brent A Hanks, Jingquan Jia, Niharika B Mettu, Michael A Morse, Margot O'Neill and 3 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in AME case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Nicholas C DeVitoDuke Cancer Institute, Durham, NC, USA.
Colm KelleherDepartment of Radiology, Duke University, Durham, NC, USA.
Kyle C StricklandDepartment of Pathology, Duke University, Durham, NC, USA.
James AbbruzzeseDuke Cancer Institute, Durham, NC, USA.
Carey AndersDuke Cancer Institute, Durham, NC, USA.
Brent A HanksDuke Cancer Institute, Durham, NC, USA.
Jingquan JiaDuke Cancer Institute, Durham, NC, USA.
Niharika B MettuDuke Cancer Institute, Durham, NC, USA.
Michael A MorseDuke Cancer Institute, Durham, NC, USA.
Margot O'NeillDuke Cancer Institute, Durham, NC, USA.
Hope UronisDuke Cancer Institute, Durham, NC, USA.
Yousuf ZafarDuke Cancer Institute, Durham, NC, USA.
John H StricklerDuke Cancer Institute, Durham, NC, USA.
Duke Cancer InstituteDuke Medical Center · USDuke University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Melanoma-mediated Dendritic Cell Tolerization and Immune EvasionK08CA191063 · NCI · DUKE UNIVERSITY · PI HANKS, BRENT ALLEN · 2015 to 2019
$826k
NCI NIH HHS K08 CA191063NCI NIH HHS P30 CA014236
6 · The paper itself

Abstract

Pancreatic adenocarcinoma commonly presents as metastatic disease and harbors a dire prognosis due to its aggressive behavior, propensity for resistance to therapies, and lack of targetable driver mutations. Additionally, despite advances in other cancers, immunotherapy has been ineffective in this disease thus far and treatment remains centered around cytotoxic chemotherapy. Here, we present a case of a patient with pancreatic adenocarcinoma harboring both high microsatellite instability (MSI-H) and

Indexed as

brain metastasiscase reportHER2 amplificationMicrosatellite instability (MSI)pancreatic cancer

Identifiers

PMID33912803
PMCPMC8060150
OpenAlexW3156400528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.