Evidence map›Paper›PMID 33912798›Full record

SynthesisGeneral psychiatry2021

Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a systematic review and meta-analysis.

Matt Pelton, Matt Ciarletta, Holly Wisnousky, Nicholas Lazzara, Monica Manglani, Djibril M Ba, Vernon M Chinchillli, Ping Du, Anna E Ssentongo, Paddy Ssentongo

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in General psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Adversity and Suicidality: Exploring Longitudinal Risk and Protective Factors in Adolescent Boys.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Matt Pelton *Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Matt Ciarletta *Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-1576-2708
Holly WisnouskyDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Nicholas LazzaraDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Monica ManglaniDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Djibril M BaDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Vernon M ChinchillliDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Ping DuDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Anna E SsentongoDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Paddy SsentongoDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-1565-5731
Pennsylvania State University · US

Funding

Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious DiseaseR01AI145057 · NIAID · YALE UNIVERSITY · PI SCHIFF, STEVEN J · 2018 to 2022
$8.1M
NIAID NIH HHS R01 AI145057
6 · The paper itself

Abstract

backgroundPeople living with HIV/AIDS (PLWHA) must contend with a significant burden of disease. However, current studies of this demographic have yielded wide variations in the incidence of suicidality (defined as suicidal ideation, suicide attempt and suicide deaths).

aimsThis systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.

methodsPublications were identified from PubMed (MEDLINE), SCOPUS, OVID (MEDLINE), Joanna Briggs Institute EBP and Cochrane Library databases (from inception to before 1 February 2020). The search strategy included a combination of Medical Subject Headings associated with suicide and HIV. Researchers independently screened records, extracted outcome measures and assessed study quality. Data were pooled using a random-effects model. Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity. Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.

resultsA total of 185 199 PLWHA were identified from 40 studies (12 cohorts, 27 cross-sectional and 1 nested case-control). The overall incidence of suicide completion in PLWHA was 10.2/1000 persons (95%CI: 4.5 to 23.1), translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons. The lifetime prevalence of suicide attempts was 158.3/1000 persons (95%CI: 106.9 to 228.2) and of suicidal ideation was 228.3/1000 persons (95%CI: 150.8 to 330.1). Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease (AIDS), the risk of suicide completion increased by 34 per 1000 persons. The quality of evidence by Grading of Recommendations, Assessment, Development and Evaluations for the suicide deaths was graded as 'moderate' quality.

conclusionsThe risk of suicide death is 100-fold higher in people living with HIV than in the general population. Lifetime incidence of suicidal ideation and attempts are substantially high. Suicide risk assessments should be a priority in PLWHA, especially for those with more advanced disease.

Indexed as

attemptedmodelsneuropsychiatrystatisticalsuicidal ideationsuicide

Identifiers

PMID33912798
PMCPMC8042999
OpenAlexW3153063687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.