Evidence map›Paper›PMID 33912760›Full record

ArticleKidney international reports2021

Functional and Genetic Landscape of Complement Dysregulation Along the Spectrum of Thrombotic Microangiopathy and its Potential Implications on Clinical Outcomes.

Sjoerd A M E G Timmermans, Jan G M C Damoiseaux, Alexis Werion, Chris P Reutelingsperger, Johann Morelle, Pieter van Paassen

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Rationale of Complement Blockade of the MCPInternational journal of molecular sciences · 2023
    Review
  10. Article
  11. Observational
  12. Application of C5 inhibitors in glomerular diseases in 2021.Kidney research and clinical practice · 2022
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sjoerd A M E G TimmermansDepartment of Nephrology and Clinical Immunology.
Jan G M C DamoiseauxCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
Alexis WerionDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Chris P ReutelingspergerDepartment of Biochemistry, Cardiovascular Research Institute, Maastricht, The Netherlands.
Johann MorelleDivision of Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Pieter van PaassenDepartment of Nephrology and Clinical Immunology.
Maastricht University · NLCliniques Universitaires Saint-Luc · BEDirectorate-General Joint Research Centre · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe syndromes of thrombotic microangiopathy (TMA) are diverse and represent severe endothelial damage caused by various mechanisms. The complement system plays a major role in a subset of patients with TMA, and its recognition is of clinical importance because it guides choice and duration of treatment.

methodsWe studied a well-defined cohort of patients with TMA and hypothesized that assessment of serum-induced

resultsMassive

conclusions

Indexed as

atypical hemolytic uremic syndromecomplementeculizumabhypertensive emergencykidney transplantationpregnancythrombotic microangiopathy

Identifiers

PMID33912760
PMCPMC8071658
OpenAlexW3128953896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.