Evidence map›Paper›PMID 33912676›Full record

ReviewCannabis and cannabinoid research2021

Cannabis and the Gut-Brain Axis Communication in HIV Infection.

Natalie L Wilson, Scott N Peterson, Ronald J Ellis

Open access · greenAbstract readReview
In one paragraph

Review in Cannabis and cannabinoid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Natalie L WilsonDepartment of Community Health Systems, School of Nursing, University of California, San Francisco, San Francisco, California, USA.
Scott N PetersonSanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Ronald J EllisDepartments of Neurosciences and Psychiatry, University of California, San Diego, San Diego, California, USA.
Sanford Burnham Prebys Medical Discovery Institute · USUniversity of California, San Francisco · USUniversity of San Diego · US

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
HIV/AIDS NURSING CARE AND PREVENTIONT32NR007081 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAWSON-ROSE, CAROL, VLAHOV, DAVID · 1995 to 2016
$3.8M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Effect of Cannabis Administration and Endocannabinoids on HIV Neuropathic PainR01DA043430 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLIS, RONALD J., HENRY, BROOK · 2017 to 2020
$2.4M
NIAID NIH HHS R24 AI067039NIDA NIH HHS R01 DA043430NIMH NIH HHS P30 MH062512NIMH NIH HHS R25 MH083620NINR NIH HHS T32 NR007081
6 · The paper itself

Abstract

People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut-brain axis signaling, and chronic inflammation. The endocannabinoid system regulates homeostasis of multiple organ systems. When deficient, dysregulation of the gut-brain axis can result in chronic inflammation and neuroinflammation. Cannabis along with the naturally occurring endocannabinoids has antioxidant and anti-inflammatory properties that can support healing and restoration as an adjunctive therapy. The purpose of this literature review is to report the physiologic mechanisms that occur in the pathology of HIV and discuss potential benefits of cannabinoids in supporting health and reducing the negative effects of comorbidities in PWH.

Indexed as

Brain-Gut AxisCannabisHIV InfectionsHumansNeuroinflammatory Diseasescannabisendocannabinoidsgut–brain axisHIVmicrobiome

Identifiers

PMID33912676
PMCPMC8064951
OpenAlexW3094753893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.